Aging-induced microbleeds of the mouse thalamus compared to sensorimotor and memory defects

Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved..

The aim of this study is to investigate the relationship between aging and brain vasculature health. Three groups of mice, 3, 17-18, and 24 months, comparable to young adult, middle age, and old human were studied. Prussian blue histology and fast imaging with steady precession T2∗-weighted magnetic resonance imaging were used to quantify structural changes in the brain across age groups. The novel object recognition test was used to assess behavioral changes associated with anatomical changes. This study is the first to show that the thalamus is the most vulnerable brain region in the mouse model for aging-induced vascular damage. Magnetic resonance imaging data document the timeline of accumulation of thalamic damage. Histological data reveal that the majority of vascular damage accumulates in the ventroposterior nucleus and mediodorsal thalamic nucleus. Functional studies indicate that aging-induced vascular damage in the thalamus is associated with memory and sensorimotor deficits. This study points to the possibility that aging-associated vascular disease is a factor in irreversible brain damage as early as middle age.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:100

Enthalten in:

Neurobiology of aging - 100(2021) vom: 12. Apr., Seite 39-47

Sprache:

Englisch

Beteiligte Personen:

Wang, Yandan [VerfasserIn]
Taylor, Erik [VerfasserIn]
Zikopoulos, Basilis [VerfasserIn]
Seta, Francesca [VerfasserIn]
Huang, Nasi [VerfasserIn]
Hamilton, James A [VerfasserIn]
Kantak, Kathleen M [VerfasserIn]
Morgan, Kathleen G [VerfasserIn]

Links:

Volltext

Themen:

Aortic stiffness
Brain bleeds
Covert stroke
Dementia
Journal Article
Research Support, N.I.H., Extramural
Sensorimotor dysfunction

Anmerkungen:

Date Completed 08.11.2021

Date Revised 26.02.2024

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.neurobiolaging.2020.11.017

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM320393046