Reversible (Patho)Physiologically Relevant Test Interventions : Rationale and Examples
Renal tissue hypoperfusion and hypoxia are early key elements in the pathophysiology of acute kidney injury of various origins, and may also promote progression from acute injury to chronic kidney disease. Here we describe test interventions that are used to study the control of renal hemodynamics and oxygenation in experimental animals in the context of kidney-specific control of hemodynamics and oxygenation. The rationale behind the use of the individual tests, the physiological responses of renal hemodynamics and oxygenation, the use in preclinical studies, and the possible application in humans are discussed.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:2216 |
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| Enthalten in: |
Methods in molecular biology (Clifton, N.J.) - 2216(2021) vom: 21., Seite 57-73 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cantow, Kathleen [VerfasserIn] |
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| Links: |
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| Themen: |
Biomarkers |
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| Anmerkungen: |
Date Completed 26.03.2021 Date Revised 30.11.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1007/978-1-0716-0978-1_4 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM320383075 |
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| 520 | |a Renal tissue hypoperfusion and hypoxia are early key elements in the pathophysiology of acute kidney injury of various origins, and may also promote progression from acute injury to chronic kidney disease. Here we describe test interventions that are used to study the control of renal hemodynamics and oxygenation in experimental animals in the context of kidney-specific control of hemodynamics and oxygenation. The rationale behind the use of the individual tests, the physiological responses of renal hemodynamics and oxygenation, the use in preclinical studies, and the possible application in humans are discussed.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Fekete, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Hosszu, Adam |e verfasserin |4 aut | |
| 700 | 1 | |a Seeliger, Erdmann |e verfasserin |4 aut | |
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