Hypolipidemic properties of Chlorella pyrenoidosa organic acids via AMPK/HMGCR/SREBP-1c pathway in vivo

© 2020 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC..

The aim of this study was to explore the effects and mechanisms of 95% ethanol extract of Chlorella pyrenoidosa (CPE95) on lipid metabolism in hyperlipidemic rats. For the sake of chemical composition analysis of CPE95, liquid chromatography-mass spectrometry (LC-MS) was used for determination. After treatment with CPE95, serum high-density lipoprotein cholesterol content of the hyperlipidemic rats was increased, while the contents of cholesterol, triglyceride, and low-density lipoprotein cholesterol were decreased strikingly. Moreover, the result of histopathology analysis showed that the accumulation and fatty deformation of the livers were relieved. Real-time quantitative PCR and Western blotting were used to determine the expression levels of lipid metabolism-related genes. The gene expression level of adenosine 5'-monophosphate-activated protein kinase was descended, and expressions of sterol regulatory element-binding protein-1c, acetyl-CoA carboxylase, and 3-hydroxy-3-methylglutaryl coenzyme A reductase were all downregulated in the CPE95-treated rats. It suggested that CPE95 may effectively improve the hyperlipidemia in rats and would be potential for functional food component to reduce blood lipid.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:9

Enthalten in:

Food science & nutrition - 9(2021), 1 vom: 22. Jan., Seite 459-468

Sprache:

Englisch

Beteiligte Personen:

Chen, Jie [VerfasserIn]
Gong, Shiyu [VerfasserIn]
Wan, Xuzhi [VerfasserIn]
Gao, Xiaoxiang [VerfasserIn]
Wang, Change [VerfasserIn]
Zeng, Feng [VerfasserIn]
Zhao, Chao [VerfasserIn]
Liu, Bin [VerfasserIn]
Huang, Ying [VerfasserIn]

Links:

Volltext

Themen:

AMPK signaling pathway
Chlorella pyrenoidosa
Ethanol extract
Hypolipidemic
Journal Article
Lipid metabolism

Anmerkungen:

Date Revised 22.01.2021

published: Electronic-eCollection

Citation Status PubMed-not-MEDLINE

doi:

10.1002/fsn3.2014

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM320356574