Acyl Fluorides from Carboxylic Acids, Aldehydes, or Alcohols under Oxidative Fluorination
We describe a novel reagent system to obtain acyl fluorides directly from three different functional group precursors: carboxylic acids, aldehydes, or alcohols. The transformation is achieved via a combination of trichloroisocyanuric acid and cesium fluoride, which facilitates the synthesis of various acyl fluorides in high yield (up to 99%). It can be applied to the late-stage functionalization of natural products and drug molecules that contain a carboxylic acid, an aldehyde, or an alcohol group.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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| Enthalten in: |
Organic letters - 23(2021), 3 vom: 05. Feb., Seite 847-852 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liang, Yumeng [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 11.06.2021 Date Revised 11.06.2021 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1021/acs.orglett.0c04087 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM32026579X |
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a We describe a novel reagent system to obtain acyl fluorides directly from three different functional group precursors: carboxylic acids, aldehydes, or alcohols. The transformation is achieved via a combination of trichloroisocyanuric acid and cesium fluoride, which facilitates the synthesis of various acyl fluorides in high yield (up to 99%). It can be applied to the late-stage functionalization of natural products and drug molecules that contain a carboxylic acid, an aldehyde, or an alcohol group | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Zhao, Zhengyu |e verfasserin |4 aut | |
| 700 | 1 | |a Taya, Akihito |e verfasserin |4 aut | |
| 700 | 1 | |a Shibata, Norio |e verfasserin |4 aut | |
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