Outstanding Drug-Loading/Release Capacity of Hollow Fe-Metal-Organic Framework-Based Microcapsules : A Potential Multifunctional Drug-Delivery Platform

Owing to their characteristic structures, metal-organic frameworks (MOFs) are considered as the leading candidate for drug-delivery materials. However, controlling the synthesis of MOFs with uniform morphology and high drug-loading/release efficiencies is still challenging, which greatly limits their applications and promotion. Herein, a multifunctional MOF-based drug-delivery system (DDS) with a controlled pore size of 100-200 nm for both therapeutic and bioimaging purposes was successfully synthesized in one step. Fe-MOF-based microcapsules were synthesized through a competitive coordination method, which was profited from the intrinsic coordination characteristics of the Fe element and the host-guest supramolecular interactions between Fe3+ and polyoxometalates anions. This as-synthesized macroporous DDS could greatly increase the drug-loading/release rate (77%; 83%) and serve as a magnetic resonance (MR) contrast agent. Because an Fe-containing macroporous DDS presents ultrahigh drug loading/release, the obtained 5-FU/Fe-MOF-based microcapsules displayed good biocompatibility, extremely powerful inhibition of tumor growth, and satisfactory MR imaging capability. Given all these advantages, this study integrates high therapeutic effect and diagnostic capability via a simple and effective morphology-controlling strategy, aiming at further facilitating the applications of MOFs in multifunctional drug delivery.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:60

Enthalten in:

Inorganic chemistry - 60(2021), 3 vom: 01. Feb., Seite 1664-1671

Sprache:

Englisch

Beteiligte Personen:

Cui, Ruixue [VerfasserIn]
Zhao, Pengfei [VerfasserIn]
Yan, Yali [VerfasserIn]
Bao, Gegentuya [VerfasserIn]
Damirin, Alatangaole [VerfasserIn]
Liu, Zhiliang [VerfasserIn]

Links:

Volltext

Themen:

Antimetabolites, Antineoplastic
Drug Carriers
E1UOL152H7
Fluorouracil
Iron
Journal Article
Metal-Organic Frameworks
U3P01618RT

Anmerkungen:

Date Completed 15.06.2021

Date Revised 15.06.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1021/acs.inorgchem.0c03156

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM319978028