Postnatal AVP treatments prevent social deficit in adolescence of valproic acid-induced rat autism model

Copyright © 2021 Elsevier Inc. All rights reserved..

Studies have shown that arginine-vasopressin (AVP) is an important neuropeptide regulating social behaviors. The present work aimed to detect changes in the AVP numbers and level in a valproic acid (VPA)-induced rat model of autism and the underlying mechanism of its pathogenesis. Our results indicated that infants exposed to VPA showed obviously impaired communication and repetitive behaviors with reduced number of AVP-ir cells in paraventricular nucleus (PVN) and cerebrospinal fluid (CSF). The postnatal subcutaneous injection of AVP can alleviate social preference deficits and stereotyped behaviors, accompanied with the increase of the AVP concentrations in the CSF. We concluded that AVP system was involved in etiology of VPA-induced autism-like symptoms and postnatal AVP treatment rescued the behavioral deficits,which could be a promising treatment for autism.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:137

Enthalten in:

Peptides - 137(2021) vom: 01. März, Seite 170493

Sprache:

Englisch

Beteiligte Personen:

Wu, Jing [VerfasserIn]
Dai, Yu-Chuan [VerfasserIn]
Lan, Xing-Yu [VerfasserIn]
Zhang, Hong-Feng [VerfasserIn]
Bai, Shu-Zhen [VerfasserIn]
Hu, Ying [VerfasserIn]
Han, Song-Ping [VerfasserIn]
Han, Ji-Sheng [VerfasserIn]
Zhang, Rong [VerfasserIn]

Links:

Volltext

Themen:

11000-17-2
113-79-1
614OI1Z5WI
AVP protein, human
AVP therapy
AVP-ir neuron numbers
Arginine Vasopressin
Autism spectrum disorder
Autism-like behavior
Journal Article
Neurophysins
Protein Precursors
Research Support, Non-U.S. Gov't
Valproic Acid
Vasopressins

Anmerkungen:

Date Completed 27.12.2021

Date Revised 27.12.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.peptides.2021.170493

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM31986166X