Severe Maternal Morbidity and Risk of Mortality Beyond the Postpartum Period
Copyright © 2021 by the American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved..
OBJECTIVE: To examine long-term risks of mortality after a pregnancy complicated by severe maternal morbidity.
METHODS: We analyzed a longitudinal cohort of 1,229,306 women who delivered in the province of Quebec, Canada from 1989 through 2016. Severe maternal morbidity included conditions such as cerebrovascular accidents, acute renal failure, severe preeclampsia, and other life-threatening complications. The outcome was in-hospital mortality after the last pregnancy, categorized as postpartum (42 days or fewer after delivery) and long-term (43 days to 29 years after delivery). We estimated hazard ratios (HRs) ofr mortality with 95% CI for severe maternal morbidity compared with no severe morbidity, using Cox regression models adjusted for maternal characteristics.
RESULTS: Severe maternal morbidity occurred in 2.9% of women. The mortality rate associated with severe maternal morbidity was 0.86 per 1,000 person-years compared with 0.41 per 1,000 person-years for no morbidity. Compared with no morbidity, severe maternal morbidity was associated with two times the rate of death any time after delivery (95% CI 1.81-2.20). Severe cardiac complications (HR 7.00, 85% CI 4.94-9.91), acute renal failure (HR 4.35, 95% CI 2.66-7.10), and cerebrovascular accidents (HR 4.03, 95% CI 2.17-7.48) were the leading morbidities associated with mortality after 42 days.
CONCLUSION: Women who experience severe maternal morbidity have an accelerated risk of mortality beyond the postpartum period compared with women who do not experience severe morbidity. More intensive clinical follow-up may be merited for women with serious pregnancy complications.
| Errataetall: |
ErratumIn: Obstet Gynecol. 2021 Apr 1;137(4):754. - PMID 33759826 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:137 |
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| Enthalten in: |
Obstetrics and gynecology - 137(2021), 2 vom: 01. Feb., Seite 277-284 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ukah, U Vivian [VerfasserIn] |
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| Anmerkungen: |
Date Completed 16.04.2021 Date Revised 19.07.2021 published: Print ErratumIn: Obstet Gynecol. 2021 Apr 1;137(4):754. - PMID 33759826 Citation Status MEDLINE |
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| doi: |
10.1097/AOG.0000000000004223 |
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| funding: |
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NLM319799409 |
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| 500 | |a Date Completed 16.04.2021 | ||
| 500 | |a Date Revised 19.07.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a ErratumIn: Obstet Gynecol. 2021 Apr 1;137(4):754. - PMID 33759826 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 by the American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved. | ||
| 520 | |a OBJECTIVE: To examine long-term risks of mortality after a pregnancy complicated by severe maternal morbidity | ||
| 520 | |a METHODS: We analyzed a longitudinal cohort of 1,229,306 women who delivered in the province of Quebec, Canada from 1989 through 2016. Severe maternal morbidity included conditions such as cerebrovascular accidents, acute renal failure, severe preeclampsia, and other life-threatening complications. The outcome was in-hospital mortality after the last pregnancy, categorized as postpartum (42 days or fewer after delivery) and long-term (43 days to 29 years after delivery). We estimated hazard ratios (HRs) ofr mortality with 95% CI for severe maternal morbidity compared with no severe morbidity, using Cox regression models adjusted for maternal characteristics | ||
| 520 | |a RESULTS: Severe maternal morbidity occurred in 2.9% of women. The mortality rate associated with severe maternal morbidity was 0.86 per 1,000 person-years compared with 0.41 per 1,000 person-years for no morbidity. Compared with no morbidity, severe maternal morbidity was associated with two times the rate of death any time after delivery (95% CI 1.81-2.20). Severe cardiac complications (HR 7.00, 85% CI 4.94-9.91), acute renal failure (HR 4.35, 95% CI 2.66-7.10), and cerebrovascular accidents (HR 4.03, 95% CI 2.17-7.48) were the leading morbidities associated with mortality after 42 days | ||
| 520 | |a CONCLUSION: Women who experience severe maternal morbidity have an accelerated risk of mortality beyond the postpartum period compared with women who do not experience severe morbidity. More intensive clinical follow-up may be merited for women with serious pregnancy complications | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Dayan, Natalie |e verfasserin |4 aut | |
| 700 | 1 | |a Potter, Brian J |e verfasserin |4 aut | |
| 700 | 1 | |a Ayoub, Aimina |e verfasserin |4 aut | |
| 700 | 1 | |a Auger, Nathalie |e verfasserin |4 aut | |
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