Symptoms and recovery among adult outpatients with and without COVID-19 at 11 healthcare facilities-July 2020, United States
© Published 2020. This article is a U.S. Government work and is in the public domain in the USA. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd..
BACKGROUND: Symptoms of mild COVID-19 illness are non-specific and may persist for prolonged periods. Effects on quality of life of persistent poor physical or mental health associated with COVID-19 are not well understood.
METHODS: Adults aged ≥18 years with laboratory-confirmed COVID-19 and matched control patients who tested negative for SARS-CoV-2 infection at outpatient facilities associated with 11 medical centers in the United States were interviewed to assess symptoms, illness duration, and health-related quality of life. Duration of symptoms, health-related quality of life measures, and days of poor physical health by symptoms experienced during illness were compared between case patients and controls using Wilcoxon rank-sum tests. Symptoms associated with COVID-19 case status were evaluated by multivariable logistic regression.
RESULTS: Among 320 participants included, 157 were COVID-19 cases and 163 were SARS-CoV-2 negative controls. Loss of taste or smell was reported by 63% of cases and 6% of controls and was strongly associated with COVID-19 in logistic regression models (adjusted odds ratio [aOR] = 32.4; 95% confidence interval [CI], 12.6-83.1). COVID-19 cases were more likely than controls to have experienced fever, body aches, weakness, or fatigue during illness, and to report ≥1 persistent symptom more than 14 days after symptom onset (50% vs 32%, P < .001). Cases reported significantly more days of poor physical health during the past 14 days than controls (P < .01).
CONCLUSIONS: Differentiating COVID-19 from other acute illnesses will require widespread diagnostic testing, especially during influenza seasons. Persistent COVID-19-related symptoms may negatively affect quality of life, even among those initially presenting with mild illness.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Influenza and other respiratory viruses - 15(2021), 3 vom: 14. Mai, Seite 345-351 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Fisher, Kiva A [VerfasserIn] |
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| Links: |
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| Themen: |
Anosmia |
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| Anmerkungen: |
Date Completed 05.05.2021 Date Revised 05.05.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/irv.12832 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Symptoms and recovery among adult outpatients with and without COVID-19 at 11 healthcare facilities-July 2020, United States |
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| 500 | |a Date Revised 05.05.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Published 2020. This article is a U.S. Government work and is in the public domain in the USA. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd. | ||
| 520 | |a BACKGROUND: Symptoms of mild COVID-19 illness are non-specific and may persist for prolonged periods. Effects on quality of life of persistent poor physical or mental health associated with COVID-19 are not well understood | ||
| 520 | |a METHODS: Adults aged ≥18 years with laboratory-confirmed COVID-19 and matched control patients who tested negative for SARS-CoV-2 infection at outpatient facilities associated with 11 medical centers in the United States were interviewed to assess symptoms, illness duration, and health-related quality of life. Duration of symptoms, health-related quality of life measures, and days of poor physical health by symptoms experienced during illness were compared between case patients and controls using Wilcoxon rank-sum tests. Symptoms associated with COVID-19 case status were evaluated by multivariable logistic regression | ||
| 520 | |a RESULTS: Among 320 participants included, 157 were COVID-19 cases and 163 were SARS-CoV-2 negative controls. Loss of taste or smell was reported by 63% of cases and 6% of controls and was strongly associated with COVID-19 in logistic regression models (adjusted odds ratio [aOR] = 32.4; 95% confidence interval [CI], 12.6-83.1). COVID-19 cases were more likely than controls to have experienced fever, body aches, weakness, or fatigue during illness, and to report ≥1 persistent symptom more than 14 days after symptom onset (50% vs 32%, P < .001). Cases reported significantly more days of poor physical health during the past 14 days than controls (P < .01) | ||
| 520 | |a CONCLUSIONS: Differentiating COVID-19 from other acute illnesses will require widespread diagnostic testing, especially during influenza seasons. Persistent COVID-19-related symptoms may negatively affect quality of life, even among those initially presenting with mild illness | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a anosmia | |
| 650 | 4 | |a convalescence | |
| 650 | 4 | |a quality of life | |
| 650 | 4 | |a recovery | |
| 650 | 4 | |a symptoms duration | |
| 700 | 1 | |a Olson, Samantha M |e verfasserin |4 aut | |
| 700 | 1 | |a Tenforde, Mark W |e verfasserin |4 aut | |
| 700 | 1 | |a Self, Wesley H |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Lindsell, Christopher J |e verfasserin |4 aut | |
| 700 | 1 | |a Shapiro, Nathan I |e verfasserin |4 aut | |
| 700 | 1 | |a Files, D Clark |e verfasserin |4 aut | |
| 700 | 1 | |a Gibbs, Kevin W |e verfasserin |4 aut | |
| 700 | 1 | |a Erickson, Heidi L |e verfasserin |4 aut | |
| 700 | 1 | |a Prekker, Matthew E |e verfasserin |4 aut | |
| 700 | 1 | |a Steingrub, Jay S |e verfasserin |4 aut | |
| 700 | 1 | |a Exline, Matthew C |e verfasserin |4 aut | |
| 700 | 1 | |a Henning, Daniel J |e verfasserin |4 aut | |
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| 700 | 1 | |a Feldstein, Leora R |e verfasserin |4 aut | |
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