Trans-Acting Effectors Versus RNA Cis-Elements : A Tightly Knit Regulatory Mesh
Copyright © 2020 Carrier, Ng Kwan Lim, Jeannotte and Massé..
Prokaryotic organisms often react instantly to environmental variations to ensure their survival. They can achieve this by rapidly and specifically modulating translation, the critical step of protein synthesis. The translation machinery responds to an array of cis-acting elements, located on the RNA transcript, which dictate the fate of mRNAs. These cis-encoded elements, such as RNA structures or sequence motifs, interact with a variety of regulators, among them small regulatory RNAs. These small regulatory RNAs (sRNAs) are especially effective at modulating translation initiation through their interaction with cis-encoded mRNA elements. Here, through selected examples of canonical and non-canonical regulatory events, we demonstrate the intimate connection between mRNA cis-encoded features and sRNA-dependent translation regulation. We also address how sRNA-based mechanistic studies can drive the discovery of new roles for cis-elements. Finally, we briefly overview the challenges of using translation regulation by synthetic regulators as a tool.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
|---|---|
| Enthalten in: |
Frontiers in microbiology - 11(2020) vom: 18., Seite 609237 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Carrier, Marie-Claude [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Cis regulatory elements |
|---|
| Anmerkungen: |
Date Revised 02.01.2021 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.3389/fmicb.2020.609237 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM319487180 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM319487180 | ||
| 003 | DE-627 | ||
| 005 | 20231225171539.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3389/fmicb.2020.609237 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1064.xml |
| 035 | |a (DE-627)NLM319487180 | ||
| 035 | |a (NLM)33384678 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Carrier, Marie-Claude |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Trans-Acting Effectors Versus RNA Cis-Elements |b A Tightly Knit Regulatory Mesh |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 02.01.2021 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2020 Carrier, Ng Kwan Lim, Jeannotte and Massé. | ||
| 520 | |a Prokaryotic organisms often react instantly to environmental variations to ensure their survival. They can achieve this by rapidly and specifically modulating translation, the critical step of protein synthesis. The translation machinery responds to an array of cis-acting elements, located on the RNA transcript, which dictate the fate of mRNAs. These cis-encoded elements, such as RNA structures or sequence motifs, interact with a variety of regulators, among them small regulatory RNAs. These small regulatory RNAs (sRNAs) are especially effective at modulating translation initiation through their interaction with cis-encoded mRNA elements. Here, through selected examples of canonical and non-canonical regulatory events, we demonstrate the intimate connection between mRNA cis-encoded features and sRNA-dependent translation regulation. We also address how sRNA-based mechanistic studies can drive the discovery of new roles for cis-elements. Finally, we briefly overview the challenges of using translation regulation by synthetic regulators as a tool | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a cis regulatory elements | |
| 650 | 4 | |a regulatory mechanisms | |
| 650 | 4 | |a small regulatory RNAs | |
| 650 | 4 | |a translational determinants | |
| 650 | 4 | |a translational enhancers | |
| 650 | 4 | |a translational regulation | |
| 700 | 1 | |a Ng Kwan Lim, Evelyne |e verfasserin |4 aut | |
| 700 | 1 | |a Jeannotte, Gabriel |e verfasserin |4 aut | |
| 700 | 1 | |a Massé, Eric |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Frontiers in microbiology |d 2010 |g 11(2020) vom: 18., Seite 609237 |w (DE-627)NLM208040617 |x 1664-302X |7 nnns |
| 773 | 1 | 8 | |g volume:11 |g year:2020 |g day:18 |g pages:609237 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3389/fmicb.2020.609237 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 11 |j 2020 |b 18 |h 609237 | ||