Biocidal Polymers : Synthesis, Characterization and Antimicrobial Activity of Bis-Quaternary Onium Salts of Poly(aspartate-co-succinimide)

Microbial multidrug resistance presents a real problem to human health. Therefore, water-soluble polymers based on poly(aspartate-co-succinimide) were synthesized via reaction of poly(aspartate-co-succinimide) with bis-quaternary ammonium or quaternary salts. The resultant copolymers were characterized by various techniques such as FTIR, TGA, 1HNMR, 13CNMR and elemental microanalysis. Antimicrobial activities of the new onium salts were investigated against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Salmonella typhi, and the fungi; Candida albicans,Aspergillus niger, Cryptococcus neoformans and Aspergillus flavus by agar diffusion method. Antimicrobial activity was studied in terms of inhibition zone diameters, in addition to the estimation of minimal inhibitory concentration (MIC) of the prepared compounds. A. niger and E. coli were the most affected microorganisms among the tested microorganisms with an inhibition zone of 19-21 (mm) in case of biocides, (V) and (VII). The obtained results showed that the quaternary onium salts have higher activity compared to the aspartate copolymer with MIC concentrations of 25 mg/mL for (VII) and (V) and 50 mg/mL for (VI) and (IV).

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:13

Enthalten in:

Polymers - 13(2020), 1 vom: 23. Dez.

Sprache:

Englisch

Beteiligte Personen:

El-Newehy, Mohamed H [VerfasserIn]
A, Meera Moydeen [VerfasserIn]
Aldalbahi, Ali K [VerfasserIn]
Thamer, Badr M [VerfasserIn]
Mahmoud, Yehia A-G [VerfasserIn]
El-Hamshary, Hany [VerfasserIn]

Links:

Volltext

Themen:

Antimicrobial activity
Journal Article
Poly(aspartate-co-succinimide)
Quaternary salts
Water-soluble polymers

Anmerkungen:

Date Revised 12.01.2021

published: Electronic

Citation Status PubMed-not-MEDLINE

doi:

10.3390/polym13010023

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM319388670