A ratiometric fluorescent probe based on quinoline for monitoring and imaging of Leucine aminopeptidase in liver tumor cells
Copyright © 2020. Published by Elsevier B.V..
Leucine aminopeptidase (LAP) is known as an important potential biomarker for liver malignancy and it is urgent to develop an intuitive and effective method to monitor the activity of LAP in liver cancer. Although, numerous LAP fluorescent probes had been developed, it is still a challenge to detect LAP activity in liver cancer. Herein, combained with the DFT, we reported a novel galactose-appended hepatoma-specific ratiometric fluorescent probe (Gal-QL-Leu) based on quinoline group for imaging and tracing LAP in liver tumor cells. Probe Gal-QL-Leu demonstrated a obvious ratiometric characteristics, better selectivity, good biocompatibility and high sensitivity. Moreover, the selective imaging of LAP in HepG2, HCT116, A549 and HeLa cells had been achieved with probe Gal-QL-Leu, demonstrating good application prospect in the detection of LAP activity in liver tumor cells.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:249 |
|---|---|
| Enthalten in: |
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy - 249(2021) vom: 15. März, Seite 119328 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Du, Kui [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
EC 3.4.11.1 |
|---|
| Anmerkungen: |
Date Completed 14.05.2021 Date Revised 14.05.2021 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.saa.2020.119328 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM319245330 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM319245330 | ||
| 003 | DE-627 | ||
| 005 | 20231225171039.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.saa.2020.119328 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1064.xml |
| 035 | |a (DE-627)NLM319245330 | ||
| 035 | |a (NLM)33360204 | ||
| 035 | |a (PII)S1386-1425(20)31307-X | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Du, Kui |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A ratiometric fluorescent probe based on quinoline for monitoring and imaging of Leucine aminopeptidase in liver tumor cells |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 14.05.2021 | ||
| 500 | |a Date Revised 14.05.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020. Published by Elsevier B.V. | ||
| 520 | |a Leucine aminopeptidase (LAP) is known as an important potential biomarker for liver malignancy and it is urgent to develop an intuitive and effective method to monitor the activity of LAP in liver cancer. Although, numerous LAP fluorescent probes had been developed, it is still a challenge to detect LAP activity in liver cancer. Herein, combained with the DFT, we reported a novel galactose-appended hepatoma-specific ratiometric fluorescent probe (Gal-QL-Leu) based on quinoline group for imaging and tracing LAP in liver tumor cells. Probe Gal-QL-Leu demonstrated a obvious ratiometric characteristics, better selectivity, good biocompatibility and high sensitivity. Moreover, the selective imaging of LAP in HepG2, HCT116, A549 and HeLa cells had been achieved with probe Gal-QL-Leu, demonstrating good application prospect in the detection of LAP activity in liver tumor cells | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Hepatoma-specific | |
| 650 | 4 | |a Leucine aminopeptidase | |
| 650 | 4 | |a Liver cancer | |
| 650 | 4 | |a Quinoline | |
| 650 | 4 | |a Ratiometric | |
| 650 | 7 | |a Fluorescent Dyes |2 NLM | |
| 650 | 7 | |a Quinolines |2 NLM | |
| 650 | 7 | |a Leucyl Aminopeptidase |2 NLM | |
| 650 | 7 | |a EC 3.4.11.1 |2 NLM | |
| 700 | 1 | |a Sheng, Li |e verfasserin |4 aut | |
| 700 | 1 | |a Luo, Xiang |e verfasserin |4 aut | |
| 700 | 1 | |a Fan, Gang |e verfasserin |4 aut | |
| 700 | 1 | |a Shen, Dadong |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Chunlei |e verfasserin |4 aut | |
| 700 | 1 | |a Shen, Runpu |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy |d 1998 |g 249(2021) vom: 15. März, Seite 119328 |w (DE-627)NLM090551192 |x 1873-3557 |7 nnns |
| 773 | 1 | 8 | |g volume:249 |g year:2021 |g day:15 |g month:03 |g pages:119328 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.saa.2020.119328 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 249 |j 2021 |b 15 |c 03 |h 119328 | ||