Validation of a high sensitive troponin 99th percentile obtained in a general hospital

Universidad Nacional de Córdoba..

Introduction: High sensitivity cardiac Troponin T (hs-cTnT) dosage is recommended for myocardial infarction diagnosis, by applying the 99th percentile obtained from a healthy population by the manufacturer. The objective is to validate the 99th percentile in a population from our hospital (99L), compared with the manufacturer´s 99th percentile (99F) by using coronary angiography as gold standard.

Materials and Methods: Retrospective analysis of every hs-cTnT (Roche) obtained from patients admitted with acute coronary syndromes (ACS) who underwent coronary angiography between 2015 and 2018.

Results: 415 patients were included for analysis (118 females, 64.2 yo). 99F sensitivity (Sn) for significant coronary artery disease (stenosis >70%) was 83.6%, with a specificity (Sp) of 44.5%. Positive predictive value (PPV) and negative predictive value (NPV) were 77% and 55% respectively. 99L Sn was 69.7% and Sp 58.6%. PPV was 79% and NPV 46%. ROC curve was 0.641 for 99F and 0.641 for 99L.

Conclusion: Given the importance of hs-cTnT in ACS diagnosis, the 99F should be the preferred upper reference limit since the sensitivity is better, although lower compared to prior studies.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:77

Enthalten in:

Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) - 77(2020), 4 vom: 01. Dez., Seite 281-284

Sprache:

Spanisch

Weiterer Titel:

Validación de percentil 99 de troponina ultrasensible obtenido en la población de un hospital general

Beteiligte Personen:

Martínez, María Laura [VerfasserIn]
Bertazzo, Brunella Bianca [VerfasserIn]
Gonzalez Grima, Juan [VerfasserIn]
Figueroa Córdoba, Ana Virginia [VerfasserIn]
Konicoff, Mailen [VerfasserIn]
Martina, Luciana [VerfasserIn]
Rossa, Victoria [VerfasserIn]
Amuchastegui, Marcos [VerfasserIn]
Brenna, Eduardo Javier [VerfasserIn]
Salomone, Oscar [VerfasserIn]
Ferrero Guadagnoli, Adolfo [VerfasserIn]
Contreras, Alejandro Ernesto [VerfasserIn]

Links:

Volltext

Themen:

Biomarkers
Journal Article
Myocardial infarction
Troponin
Troponin T
Validation studies

Anmerkungen:

Date Completed 08.02.2021

Date Revised 08.02.2021

published: Electronic

Citation Status MEDLINE

doi:

10.31053/1853.0605.v77.n4.27473

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM319159809