Validation of a high sensitive troponin 99th percentile obtained in a general hospital
Universidad Nacional de Córdoba..
Introduction: High sensitivity cardiac Troponin T (hs-cTnT) dosage is recommended for myocardial infarction diagnosis, by applying the 99th percentile obtained from a healthy population by the manufacturer. The objective is to validate the 99th percentile in a population from our hospital (99L), compared with the manufacturer´s 99th percentile (99F) by using coronary angiography as gold standard.
Materials and Methods: Retrospective analysis of every hs-cTnT (Roche) obtained from patients admitted with acute coronary syndromes (ACS) who underwent coronary angiography between 2015 and 2018.
Results: 415 patients were included for analysis (118 females, 64.2 yo). 99F sensitivity (Sn) for significant coronary artery disease (stenosis >70%) was 83.6%, with a specificity (Sp) of 44.5%. Positive predictive value (PPV) and negative predictive value (NPV) were 77% and 55% respectively. 99L Sn was 69.7% and Sp 58.6%. PPV was 79% and NPV 46%. ROC curve was 0.641 for 99F and 0.641 for 99L.
Conclusion: Given the importance of hs-cTnT in ACS diagnosis, the 99F should be the preferred upper reference limit since the sensitivity is better, although lower compared to prior studies.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:77 |
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Enthalten in: |
Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) - 77(2020), 4 vom: 01. Dez., Seite 281-284 |
Sprache: |
Spanisch |
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Weiterer Titel: |
Validación de percentil 99 de troponina ultrasensible obtenido en la población de un hospital general |
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Beteiligte Personen: |
Martínez, María Laura [VerfasserIn] |
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Links: |
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Themen: |
Biomarkers |
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Anmerkungen: |
Date Completed 08.02.2021 Date Revised 08.02.2021 published: Electronic Citation Status MEDLINE |
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doi: |
10.31053/1853.0605.v77.n4.27473 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM319159809 |
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245 | 1 | 0 | |a Validation of a high sensitive troponin 99th percentile obtained in a general hospital |
246 | 3 | 3 | |a Validación de percentil 99 de troponina ultrasensible obtenido en la población de un hospital general |
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500 | |a published: Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Universidad Nacional de Córdoba. | ||
520 | |a Introduction: High sensitivity cardiac Troponin T (hs-cTnT) dosage is recommended for myocardial infarction diagnosis, by applying the 99th percentile obtained from a healthy population by the manufacturer. The objective is to validate the 99th percentile in a population from our hospital (99L), compared with the manufacturer´s 99th percentile (99F) by using coronary angiography as gold standard | ||
520 | |a Materials and Methods: Retrospective analysis of every hs-cTnT (Roche) obtained from patients admitted with acute coronary syndromes (ACS) who underwent coronary angiography between 2015 and 2018 | ||
520 | |a Results: 415 patients were included for analysis (118 females, 64.2 yo). 99F sensitivity (Sn) for significant coronary artery disease (stenosis >70%) was 83.6%, with a specificity (Sp) of 44.5%. Positive predictive value (PPV) and negative predictive value (NPV) were 77% and 55% respectively. 99L Sn was 69.7% and Sp 58.6%. PPV was 79% and NPV 46%. ROC curve was 0.641 for 99F and 0.641 for 99L | ||
520 | |a Conclusion: Given the importance of hs-cTnT in ACS diagnosis, the 99F should be the preferred upper reference limit since the sensitivity is better, although lower compared to prior studies | ||
650 | 4 | |a Journal Article | |
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700 | 1 | |a Figueroa Córdoba, Ana Virginia |e verfasserin |4 aut | |
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700 | 1 | |a Brenna, Eduardo Javier |e verfasserin |4 aut | |
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700 | 1 | |a Ferrero Guadagnoli, Adolfo |e verfasserin |4 aut | |
700 | 1 | |a Contreras, Alejandro Ernesto |e verfasserin |4 aut | |
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