Increased case-finding and uptake of direct-acting antiviral treatment essential for micro-elimination of hepatitis C among people living with HIV : a national record linkage study

© 2020 British HIV Association..

OBJECTIVES: Micro-elimination of hepatitis C virus (HCV) in people living with HIV (PLHIV) and co-infected with HCV has been proposed as a key contribution to the overall goal of HCV elimination. While other studies have examined micro-elimination in HIV-treated cohorts, few have considered HCV micro-elimination among those not treated for HIV or at a national level.

METHODS: Through data linkage of national and sentinel surveillance data, we examined the extent of HCV testing, diagnosis and treatment among a cohort of PLHIV in Scotland identified through the national database of HIV-diagnosed individuals, up to the end of 2017.

RESULTS: Of 5018 PLHIV, an estimated 797 (15%) had never been tested for HCV and 70 (9%) of these had undiagnosed chronic HCV. The odds of never having been tested for HCV were the highest in those not on HIV treatment [adjusted odds ratio (aOR) = 7.21, 95% confidence interval (CI): 5.15-10.10). Overall HCV antibody positivity was 11%, and it was at its highest among people who inject drugs (49%). Most of those with chronic HCV (91%) had attended an HCV treatment clinic but only half had been successfully treated (54% for those on HIV treatment, 12% for those not) by the end of 2017. The odds of never having been treated for HCV were the highest in those not on HIV treatment (aOR = 3.60, 95% CI: 1.59-8.15).

CONCLUSIONS: Our data demonstrate that micro-elimination of HCV in PLHIV is achievable but progress will require increased effort to engage and treat those co-infected, including those not being treated for their HIV.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:22

Enthalten in:

HIV medicine - 22(2021), 5 vom: 22. Mai, Seite 334-345

Sprache:

Englisch

Beteiligte Personen:

McLeod, A [VerfasserIn]
Hutchinson, S J [VerfasserIn]
Smith, S [VerfasserIn]
Leen, C [VerfasserIn]
Clifford, S [VerfasserIn]
McAuley, A [VerfasserIn]
Wallace, L A [VerfasserIn]
Barclay, S T [VerfasserIn]
Bramley, P [VerfasserIn]
Dillon, J F [VerfasserIn]
Fraser, A [VerfasserIn]
Gunson, R N [VerfasserIn]
Hayes, P C [VerfasserIn]
Kennedy, N [VerfasserIn]
Peters, E [VerfasserIn]
Templeton, K [VerfasserIn]
Goldberg, D J [VerfasserIn]

Links:

Volltext

Themen:

Antiviral Agents
Elimination
HIV
Hepatitis C
Journal Article
Micro-elimination
Record linkage
Research Support, Non-U.S. Gov't
Surveillance

Anmerkungen:

Date Completed 14.03.2022

Date Revised 14.03.2022

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1111/hiv.13032

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM319146669