Access to 1-indolyltetrahydro-β-carbolines via metal-free cross-dehydrogenative coupling : the total synthesis of eudistomin U, isoeudistomin U and 19-bromoisoeudistomin U
A highly selective and captivating metal-free cross-dehydrogenative coupling for the cross-coupling of two reactive nucleophiles such as tetrahydro-β-carboline and indoles is developed. A series of 1-indolyltetrahydro-β-carboline derivatives were synthesized in excellent to moderate yields. Temperature, time and concentration control resulted in mono indolylation selectively. Moreover, the total synthesis of eudistomin U and isoeudistomin U and the first total synthesis of 19-bromoisoeudistomin U were accomplished.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:57 |
|---|---|
| Enthalten in: |
Chemical communications (Cambridge, England) - 57(2021), 6 vom: 18. Jan., Seite 757-760 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Ranjani, Ganapathy [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 28.01.2021 Date Revised 28.01.2021 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.1039/d0cc06958b |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM319144402 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM319144402 | ||
| 003 | DE-627 | ||
| 005 | 20231225170828.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1039/d0cc06958b |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1063.xml |
| 035 | |a (DE-627)NLM319144402 | ||
| 035 | |a (NLM)33349820 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Ranjani, Ganapathy |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Access to 1-indolyltetrahydro-β-carbolines via metal-free cross-dehydrogenative coupling |b the total synthesis of eudistomin U, isoeudistomin U and 19-bromoisoeudistomin U |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 28.01.2021 | ||
| 500 | |a Date Revised 28.01.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a A highly selective and captivating metal-free cross-dehydrogenative coupling for the cross-coupling of two reactive nucleophiles such as tetrahydro-β-carboline and indoles is developed. A series of 1-indolyltetrahydro-β-carboline derivatives were synthesized in excellent to moderate yields. Temperature, time and concentration control resulted in mono indolylation selectively. Moreover, the total synthesis of eudistomin U and isoeudistomin U and the first total synthesis of 19-bromoisoeudistomin U were accomplished | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Nagarajan, Rajagopal |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Chemical communications (Cambridge, England) |d 1998 |g 57(2021), 6 vom: 18. Jan., Seite 757-760 |w (DE-627)NLM095512322 |x 1364-548X |7 nnns |
| 773 | 1 | 8 | |g volume:57 |g year:2021 |g number:6 |g day:18 |g month:01 |g pages:757-760 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1039/d0cc06958b |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 57 |j 2021 |e 6 |b 18 |c 01 |h 757-760 | ||