Intradermal delivery of receptor-binding domain of SARS-CoV-2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice
© 2020 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of The American Institute of Chemical Engineers..
The S1 subunit of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein contains an immunogenic receptor-binding domain (RBD), which is a promising candidate for the development of a potential vaccine. This study demonstrated that intradermal delivery of an S-RBD vaccine using a dissolvable microneedle skin patch can induce both significant B-cell and significant T-cell responses against S-RBD. Importantly, the outcomes were comparable to that of conventional bolus injection.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:6 |
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| Enthalten in: |
Bioengineering & translational medicine - 6(2021), 1 vom: 10. Jan., Seite e10202 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kuwentrai, Chaiyaporn [VerfasserIn] |
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| Links: |
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| Themen: |
COVID‐19 |
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| Anmerkungen: |
Date Revised 21.06.2022 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1002/btm2.10202 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM319144178 |
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| 520 | |a © 2020 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of The American Institute of Chemical Engineers. | ||
| 520 | |a The S1 subunit of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein contains an immunogenic receptor-binding domain (RBD), which is a promising candidate for the development of a potential vaccine. This study demonstrated that intradermal delivery of an S-RBD vaccine using a dissolvable microneedle skin patch can induce both significant B-cell and significant T-cell responses against S-RBD. Importantly, the outcomes were comparable to that of conventional bolus injection | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Rong, Li |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Bao-Zhong |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Ye-Fan |e verfasserin |4 aut | |
| 700 | 1 | |a Gong, Hua-Rui |e verfasserin |4 aut | |
| 700 | 1 | |a Dou, Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Deng, Jian |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Jian-Dong |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Chenjie |e verfasserin |4 aut | |
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