COVID-19 Susceptibility in Bronchial Asthma

Copyright © 2020 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved..

BACKGROUND: Bronchial asthma has not been adequately assessed in coronavirus disease 2019 (COVID-19). Respiratory allergy is associated with significant reductions in the expression of angiotensin-converting enzyme 2 receptor, which is the entry receptor for COVID-19.

OBJECTIVE: To observe COVID-19 susceptibility in patients with bronchial asthma, analyze the prevalence of asthma in a large cohort of consecutive outpatient subjects who were tested with the RT-PCR assay for COVID-19.

METHODS: This was a retrospective population-based cross-sectional study using data from a large nationwide health maintenance organization in Israel. All health maintenance organization enrollees who had been tested for COVID-19 from February to June 2020 were included. Differences in demographic and clinical characteristics between the subjects with negative and positive COVID-19 RT-PCR test results and between COVID-19 RT-PCR-positive subjects with and without asthma were analyzed.

RESULTS: A total of 37,469 subjects were tested for COVID-19 RT-PCR, and results for 2,266 (6.05%) of them were positive. A significantly higher proportion of smokers was observed in the COVID-19-negative group than in the COVID-19-positive group (4734 [13.45%] vs 103 [4.55%]; P < .001). Asthma was found in 153 (6.75 %) subjects of the COVID-19-positive group and in 3388 (9.62%) subjects of the COVID-19-negative group (P < .001). No significant impact of antileukotrienes, inhaled corticosteroids, and long-acting beta-blockers use was revealed on COVID-19 positivity proportions. Multiple logistic regression analysis adjusted for sex, age, smoking, and comorbidity revealed a negative association of asthma with the likelihood of being positive for COVID-19 (odds ratio, 0.71; 95% CI, 0.58-0.87; P = .001).

CONCLUSIONS: We observed lower COVID-19 susceptibility in patients with preexisting asthma.

Media Type:

Electronic Article

Year of Publication:

2021

Contained In:

The journal of allergy and clinical immunology. In practice - Vol. 9, No. 2 (2021), p. 684-692.e1

Language:

English

Contributors:

Green, Ilan
Merzon, Eugene
Vinker, Shlomo
Golan-Cohen, Avivit
Magen, Eli

Links:

Volltext

Keywords:

*SARS-CoV-2
Adolescent
Adult
Aged
Aged, 80 and over
Asthma
COVID-19
COVID-19 Nucleic Acid Testing
Child
Child, Preschool
Cross-Sectional Studies
Disease Susceptibility
Female
Humans
Israel
Journal Article
Male
Middle Aged
RNA, Viral
Retrospective Studies
Smoking
Susceptibility
Young Adult

Notes:

Date Completed 15.02.2021

Date Revised 15.02.2021

published: Print-Electronic

Citation Status MEDLINE

Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Physical Description:

Online-Ressource

doi:

10.1016/j.jaip.2020.11.020

PMID:

33242628

PPN (Catalogue-ID):

NLM319088235