Glycocalyx as a determining factor in development of endothelial venous dysfunction and possibilities of correction thereof

Modern vascular surgery has the data on a substantial role of the endothelium in pathogenesis of vascular diseases. Endothelial dysfunction is associated with a wide range of pathological processes including those in chronic diseases of lower-limb veins. The discovery of the endothelial glycocalyx made it possible to evaluate its role in the development of endothelial dysfunction as a trigger mechanism in impairment of venous blood flow. The understanding of the unifying role of endothelial dysfunction in pathology in various fields of medicine provides a possibility of predicting the development of serious socially significant diseases such as cardiovascular diseases, diabetes mellitus, obstetrical complications, and to correct the conditions associated therewith. The present study was aimed at carrying out a systematic literature review, thus making it possible to evaluate the role of the endothelial glycocalyx in the development of endothelial dysfunction, as well as to determine therapy with sulodexide capable of decreasing the probability of the onset of endothelial dysfunction at the expense of an anti-inflammatory, antithrombotic, and angioprotective effect on the endothelial wall.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:26

Enthalten in:

Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery - 26(2020), 4 vom: 18., Seite 71-77

Sprache:

Russisch

Weiterer Titel:

Glikokaliks – opredeliaiushchiĭ faktor v razvitii éndotelial'noĭ venoznoĭ disfunktsii i vozmozhnosti ee korrektsii

Beteiligte Personen:

Shevchenko, Iu L [VerfasserIn]
Stoĭko, Iu M [VerfasserIn]
Gudymovich, V G [VerfasserIn]
Cherniago, T Iu [VerfasserIn]

Links:

Volltext

Themen:

Anti-Inflammatory Agents
Chronic diseases of lower extremity veins
Correction of endothelial dysfunction
Endothelial dysfunction
Endothelium
Glycocalyx
Journal Article
Sulodexide
Systematic Review

Anmerkungen:

Date Completed 21.12.2020

Date Revised 21.12.2020

published: Print

Citation Status MEDLINE

doi:

10.33529/ANGIO2020404

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM318973391