Thymus atlanticus polyphenol-rich extract regulates cholesterol metabolism by inhibiting its biosynthesis without affecting its excretion in hamsters fed a high-fat diet
CONTEXT: Thymus atlanticus has been reported to have significant hypolipidaemic effect in animal models. However, the mechanism of this hypolipidaemic action still unknown.
OBJECTIVE: To determinate the possible mechanism(s) of hypolipidaemic action of a Thymus atlanticus polyphenol-rich extract (PRE).
MATERIALS AND METHODS: Plasma, faecal, and liver cholesterol, bile acid content in the faeces, and gene expression level of HMG-CoA reductase, CYP7A1, ABCG5 and ABCG8 were analysed after 9 weeks in hamsters feeding normal diet, high-fat diet (HFD) or HFD supplemented with 400 mg/kg body weight/day of PRE.
RESULTS: PRE significantly decreased total cholesterol content (p < .05) and HMG-CoA reductase expression (p < .05), but did not affect the faecal cholesterol, bile acid contents and CYP7A1 and ABCG5/G8 expression (p > .05).
CONCLUSION: We can conclude that the T. atlanticus extract is efficient in the alleviation of chronic hyperlipidaemia by acting as cholesterol biosynthesis inhibitor.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2023 |
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Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:129 |
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Enthalten in: |
Archives of physiology and biochemistry - 129(2023), 3 vom: 15. Juni, Seite 618-625 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Ramchoun, Mhamed [VerfasserIn] |
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Links: |
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Themen: |
97C5T2UQ7J |
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Anmerkungen: |
Date Completed 10.05.2023 Date Revised 10.05.2023 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1080/13813455.2020.1854308 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM318858576 |
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500 | |a Citation Status MEDLINE | ||
520 | |a CONTEXT: Thymus atlanticus has been reported to have significant hypolipidaemic effect in animal models. However, the mechanism of this hypolipidaemic action still unknown | ||
520 | |a OBJECTIVE: To determinate the possible mechanism(s) of hypolipidaemic action of a Thymus atlanticus polyphenol-rich extract (PRE) | ||
520 | |a MATERIALS AND METHODS: Plasma, faecal, and liver cholesterol, bile acid content in the faeces, and gene expression level of HMG-CoA reductase, CYP7A1, ABCG5 and ABCG8 were analysed after 9 weeks in hamsters feeding normal diet, high-fat diet (HFD) or HFD supplemented with 400 mg/kg body weight/day of PRE | ||
520 | |a RESULTS: PRE significantly decreased total cholesterol content (p < .05) and HMG-CoA reductase expression (p < .05), but did not affect the faecal cholesterol, bile acid contents and CYP7A1 and ABCG5/G8 expression (p > .05) | ||
520 | |a CONCLUSION: We can conclude that the T. atlanticus extract is efficient in the alleviation of chronic hyperlipidaemia by acting as cholesterol biosynthesis inhibitor | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a ABCG5/8 | |
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700 | 1 | |a Alibrahim, Eid Alabed |e verfasserin |4 aut | |
700 | 1 | |a Hmidani, Abdelbassat |e verfasserin |4 aut | |
700 | 1 | |a Sellam, Khalid |e verfasserin |4 aut | |
700 | 1 | |a Amrani, Souliman |e verfasserin |4 aut | |
700 | 1 | |a Harnafi, Hicham |e verfasserin |4 aut | |
700 | 1 | |a Benlyas, Mohamed |e verfasserin |4 aut | |
700 | 1 | |a Kasbi Chadli, Fatima |e verfasserin |4 aut | |
700 | 1 | |a Ouguerram, Khadija |e verfasserin |4 aut | |
700 | 1 | |a Alem, Chakib |e verfasserin |4 aut | |
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