Thymus atlanticus polyphenol-rich extract regulates cholesterol metabolism by inhibiting its biosynthesis without affecting its excretion in hamsters fed a high-fat diet

CONTEXT: Thymus atlanticus has been reported to have significant hypolipidaemic effect in animal models. However, the mechanism of this hypolipidaemic action still unknown.

OBJECTIVE: To determinate the possible mechanism(s) of hypolipidaemic action of a Thymus atlanticus polyphenol-rich extract (PRE).

MATERIALS AND METHODS: Plasma, faecal, and liver cholesterol, bile acid content in the faeces, and gene expression level of HMG-CoA reductase, CYP7A1, ABCG5 and ABCG8 were analysed after 9 weeks in hamsters feeding normal diet, high-fat diet (HFD) or HFD supplemented with 400 mg/kg body weight/day of PRE.

RESULTS: PRE significantly decreased total cholesterol content (p < .05) and HMG-CoA reductase expression (p < .05), but did not affect the faecal cholesterol, bile acid contents and CYP7A1 and ABCG5/G8 expression (p > .05).

CONCLUSION: We can conclude that the T. atlanticus extract is efficient in the alleviation of chronic hyperlipidaemia by acting as cholesterol biosynthesis inhibitor.

Medienart:

E-Artikel

Erscheinungsjahr:

2023

Erschienen:

2023

Enthalten in:

Zur Gesamtaufnahme - volume:129

Enthalten in:

Archives of physiology and biochemistry - 129(2023), 3 vom: 15. Juni, Seite 618-625

Sprache:

Englisch

Beteiligte Personen:

Ramchoun, Mhamed [VerfasserIn]
Khouya, Tarik [VerfasserIn]
Alibrahim, Eid Alabed [VerfasserIn]
Hmidani, Abdelbassat [VerfasserIn]
Sellam, Khalid [VerfasserIn]
Amrani, Souliman [VerfasserIn]
Harnafi, Hicham [VerfasserIn]
Benlyas, Mohamed [VerfasserIn]
Kasbi Chadli, Fatima [VerfasserIn]
Ouguerram, Khadija [VerfasserIn]
Alem, Chakib [VerfasserIn]

Links:

Volltext

Themen:

97C5T2UQ7J
ABCG5/8
Anticholesteremic Agents
Bile Acids and Salts
Cholesterol
Chronic hyperlipidaemia
HMG-CoA reductase
Hamsters
Journal Article
Polyphenols
Thymus atlanticus

Anmerkungen:

Date Completed 10.05.2023

Date Revised 10.05.2023

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1080/13813455.2020.1854308

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM318858576