The complement cascade at the Utah microelectrode-tissue interface

Copyright © 2020 Elsevier Ltd. All rights reserved..

Devices implanted within the central nervous system (CNS) are subjected to tissue reactivity due to the lack of biocompatibility between implanted material and the cells' microenvironment. Studies have attributed blood-brain barrier disruption, inflammation, and oxidative stress as main contributing factors that lead to electrode recording failure. The complement cascade is a part of the innate immunity that focuses on recognizing and targeting foreign objects; however, its role in the context of neural implants is substantially unknown. In this study, we implanted a non-functional 4x4 Utah microelectrode array (UEA) into the somatosensory cortex and studied the complement cascade via combined gene and immunohistochemistry quantification at acute (48-h), sub-acute (1-week), and early chronic (4-weeks) time points. The results of this study demonstrate the activation and continuation of the complement cascade at the electrode-tissue interface, illustrating the therapeutic potential of modulating the foreign body response via the complement cascade.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:268

Enthalten in:

Biomaterials - 268(2021) vom: 15. Jan., Seite 120583

Sprache:

Englisch

Beteiligte Personen:

Bennett, Cassie [VerfasserIn]
Álvarez-Ciara, Anabel [VerfasserIn]
Franklin, Melissa [VerfasserIn]
Dietrich, W Dalton [VerfasserIn]
Prasad, Abhishek [VerfasserIn]

Links:

Volltext

Themen:

Biocompatibility
Complement activating
Complement cascade
Foreign body response
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Utah arrays

Anmerkungen:

Date Completed 24.05.2021

Date Revised 02.01.2022

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.biomaterials.2020.120583

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM318758369