Orientia tsutsugamushi DNA load and genotypes in blood as a marker of severity
Copyright © 2020 Elsevier B.V. All rights reserved..
Scrub typhus is an acute febrile illness caused by Orientia tsutsugamushi and is endemic to many parts of the Asia-Pacific region. We investigated whether the genotype of O. tsutsugamushi or the DNA load would be a useful marker of disease severity in scrub typhus patients. We evaluated the clinical features, genotypes and bacterial DNA load in the blood of 118 patients, including 114 surviving and 4 non-surviving patients, admitted at Chosun University Hospital. Four patients infected with the Pajoo, Yonchon, Youngworl and Boryong genotypes died. In the 114 survivors, 100 Boryong and 2 Taguchi genotypes were identified. The genotypes involved showed significant differences between the surviving and non-surviving patients (p<0.001). The median number of O. tsutsugamushi DNA copies was 78 copies /μL (range 3,960) in surviving patients, whereas 83,800 copies/μL (range 244,600) in the non-surviving patients. We found that the genotype and DNA load in the patient's blood are useful markers of disease severity in scrub typhus.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:215 |
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| Enthalten in: |
Acta tropica - 215(2021) vom: 10. März, Seite 105786 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kim, Seok Won [VerfasserIn] |
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| Links: |
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| Themen: |
Biomarkers |
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| Anmerkungen: |
Date Completed 07.05.2021 Date Revised 07.05.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.actatropica.2020.105786 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2020 Elsevier B.V. All rights reserved. | ||
| 520 | |a Scrub typhus is an acute febrile illness caused by Orientia tsutsugamushi and is endemic to many parts of the Asia-Pacific region. We investigated whether the genotype of O. tsutsugamushi or the DNA load would be a useful marker of disease severity in scrub typhus patients. We evaluated the clinical features, genotypes and bacterial DNA load in the blood of 118 patients, including 114 surviving and 4 non-surviving patients, admitted at Chosun University Hospital. Four patients infected with the Pajoo, Yonchon, Youngworl and Boryong genotypes died. In the 114 survivors, 100 Boryong and 2 Taguchi genotypes were identified. The genotypes involved showed significant differences between the surviving and non-surviving patients (p<0.001). The median number of O. tsutsugamushi DNA copies was 78 copies /μL (range 3,960) in surviving patients, whereas 83,800 copies/μL (range 244,600) in the non-surviving patients. We found that the genotype and DNA load in the patient's blood are useful markers of disease severity in scrub typhus | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Orientia tsutsugamushi | |
| 650 | 4 | |a fatality | |
| 650 | 4 | |a scrub typhus | |
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| 650 | 7 | |a DNA, Bacterial |2 NLM | |
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| 700 | 1 | |a Neupane, Ganesh P |e verfasserin |4 aut | |
| 700 | 1 | |a Pyun, Sang-Hyun |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Byeong Jeon |e verfasserin |4 aut | |
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