The interaction between dietary approaches to stop hypertension and MC4R gene variant in predicting cardiovascular risk factors

Objective: The genetic variants near the melanocortin-4 receptor gene (MC4R), a key protein regulating energy balance and adiposity, have been related to obesity and cardiovascular risk factors. However, qualitative and quantitative aspects of diet may modulate the association of this polymorphism with obesity and cardiovascular diseases (CVDs). The aim of this study was to evaluate interactions among MC4R rs17782313, the Dietary Approaches to Stop Hypertension (DASH) diet and risk factors for CVDs. Method: This cross-sectional study was conducted on 266 Iranian women categorized by body mass index (BMI) range of 25-40 kg/m2 as overweight or obese. CVD risk factors included waist circumference (WC), lipid profile, blood pressure, insulin circulation and fasting blood sugar (FBS). Insulin and FBS were used to calculate homeostatic model assessment insulin resistance (HOMA-IR) Body composition was assessed by a multi-frequency bioelectrical impedance analyzer, InBody 770 scanner. Results: The findings of this study show that high adherence to the DASH diet in the CC groups were associated with decreased SBP and DBP compared to the TT group. In addition, a significant difference between women with high adherence to the DASH diet compared to low adherence was observed for body weight (p < 0.001), fat free mass (FFM) (p = 0.01) and BMI (p = 0.02). Women with the CC genotype had higher insulin (mg/dl) (mean and SD, for TT: 14.6 ± 4.6, TC: 17.3 ± 9.2, CC: 15.3 ± 4.8, p = 0.04) and HOMA-IR (mean for and SD, TT: 3.1 ± 1.07, TC: 3.9 ± 2.4, CC: 3.2 ± 1.1, p = 0.01) than TT group. Inclusion of potential confounding variables (age, physical activity, BMI and daily caloric intake) did not attenuate the difference. Conclusion: Among overweight/obese Iranian women with the CC genotype, incorporating the DASH diet may serve as a dietary prescription to decrease CVD risk. A dietary intervention trial is warranted.

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:92

Enthalten in:

International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition - 92(2022), 5-6 vom: 19. Okt., Seite 376-384

Sprache:

Englisch

Beteiligte Personen:

Yarizadeh, Habib [VerfasserIn]
Bahiraee, Alireza [VerfasserIn]
Asadi, Sara [VerfasserIn]
Maddahi, Niloofar Sadat [VerfasserIn]
Setayesh, Leila [VerfasserIn]
Casazza, Krista [VerfasserIn]
Mirzaei, Khadijeh [VerfasserIn]

Links:

Volltext

Themen:

Blood Glucose
Blood pressure
Cardiovascular disease
Dietary approaches to stop hypertension
Evaluation Study
Insulin
Journal Article
Lipids
MC4R
MC4R protein, human
Receptor, Melanocortin, Type 4

Anmerkungen:

Date Completed 30.09.2022

Date Revised 11.10.2022

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1024/0300-9831/a000690

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM318498995