Key Molecular Mechanisms of Aging, Biomarkers, and Potential Interventions

The mechanisms of aging are described at the molecular, cell, tissue, and systemic levels. Primary age-dependent molecular lesions activate the cell stress response to compensate for the resulting defects, but the mechanisms that recover and maintain homeostasis are gradually deteriorated. When the amount of errors reaches a critical threshold in regulatory networks, a phase transition from health to disease occurs at the systemic level. The review considers the approaches to quantitative assessment of the aging process (biomarkers of aging) and promising interventions to slow down the aging process and to reduce the risk of age-dependent diseases.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:54

Enthalten in:

Molekuliarnaia biologiia - 54(2020), 6 vom: 26. Nov., Seite 883-921

Sprache:

Russisch

Beteiligte Personen:

Proshkina, E N [VerfasserIn]
Solovev, I A [VerfasserIn]
Shaposhnikov, M V [VerfasserIn]
Moskalev, A A [VerfasserIn]

Links:

Volltext

Themen:

Age-dependent diseases
Aging
Biomarkers
Biomarkers of aging
Geroprotectors
Journal Article
Review

Anmerkungen:

Date Completed 09.12.2020

Date Revised 14.12.2020

published: Print

Citation Status MEDLINE

doi:

10.31857/S0026898420060099

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM318423588