A fast navigator (fastNAV) for prospective respiratory motion correction in first-pass myocardial perfusion imaging
© 2020 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine..
PURPOSE: To develop and evaluate a fast respiratory navigator (fastNAV) for cardiac MR perfusion imaging with subject-specific prospective slice tracking.
METHODS: A fastNAV was developed for dynamic contrast-enhanced cardiac MR perfusion imaging by combining spatially nonselective saturation with slice-selective tip-up and slice-selective excitation pulses. The excitation slice was angulated from the tip-up slice in the transverse plane to overlap only in the right hemidiaphragm for suppression of signal outside the right hemidiaphragm. A calibration scan was developed to enable the estimation of subject-specific tracking factors. Perfusion imaging using subject-specific fastNAV-based slice tracking was then compared to a conventional sequence (ie, without slice tracking) in 10 patients under free-breathing conditions. Respiratory motion in perfusion images was quantitatively assessed by measuring the average overlap of the left ventricle across images (avDice, 0:no overlap/1:perfect overlap) and the average displacement of the center of mass of the left ventricle (avCoM). Image quality was subjectively assessed using a 4-point scoring system (1: poor, 4: excellent).
RESULTS: The fastNAV calibration was successfully performed in all subjects (average tracking factor of 0.46 ± 0.13, R = 0.94 ± 0.03). Prospective motion correction using fastNAV led to higher avDice (0.94 ± 0.02 vs. 0.90 ± 0.03, P < .001) and reduced avCoM (4.03 ± 0.84 vs. 5.22 ± 1.22, P < .001). There were no statistically significant differences between the 2 sequences in terms of image quality (both sequences: median = 3 and interquartile range = 3-4, P = 1).
CONCLUSION: fastNAV enables fast and robust right hemidiaphragm motion tracking in a perfusion sequence. In combination with subject-specific slice tracking, fastNAV reduces the effect of respiratory motion during free-breathing cardiac MR perfusion imaging.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:85 |
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| Enthalten in: |
Magnetic resonance in medicine - 85(2021), 5 vom: 01. Mai, Seite 2661-2671 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mooiweer, Ronald [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 19.05.2021 Date Revised 05.10.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/mrm.28617 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM318370956 |
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| 100 | 1 | |a Mooiweer, Ronald |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A fast navigator (fastNAV) for prospective respiratory motion correction in first-pass myocardial perfusion imaging |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Completed 19.05.2021 | ||
| 500 | |a Date Revised 05.10.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine. | ||
| 520 | |a PURPOSE: To develop and evaluate a fast respiratory navigator (fastNAV) for cardiac MR perfusion imaging with subject-specific prospective slice tracking | ||
| 520 | |a METHODS: A fastNAV was developed for dynamic contrast-enhanced cardiac MR perfusion imaging by combining spatially nonselective saturation with slice-selective tip-up and slice-selective excitation pulses. The excitation slice was angulated from the tip-up slice in the transverse plane to overlap only in the right hemidiaphragm for suppression of signal outside the right hemidiaphragm. A calibration scan was developed to enable the estimation of subject-specific tracking factors. Perfusion imaging using subject-specific fastNAV-based slice tracking was then compared to a conventional sequence (ie, without slice tracking) in 10 patients under free-breathing conditions. Respiratory motion in perfusion images was quantitatively assessed by measuring the average overlap of the left ventricle across images (avDice, 0:no overlap/1:perfect overlap) and the average displacement of the center of mass of the left ventricle (avCoM). Image quality was subjectively assessed using a 4-point scoring system (1: poor, 4: excellent) | ||
| 520 | |a RESULTS: The fastNAV calibration was successfully performed in all subjects (average tracking factor of 0.46 ± 0.13, R = 0.94 ± 0.03). Prospective motion correction using fastNAV led to higher avDice (0.94 ± 0.02 vs. 0.90 ± 0.03, P < .001) and reduced avCoM (4.03 ± 0.84 vs. 5.22 ± 1.22, P < .001). There were no statistically significant differences between the 2 sequences in terms of image quality (both sequences: median = 3 and interquartile range = 3-4, P = 1) | ||
| 520 | |a CONCLUSION: fastNAV enables fast and robust right hemidiaphragm motion tracking in a perfusion sequence. In combination with subject-specific slice tracking, fastNAV reduces the effect of respiratory motion during free-breathing cardiac MR perfusion imaging | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a myocardial perfusion | |
| 650 | 4 | |a navigator | |
| 650 | 4 | |a prospective motion correction | |
| 650 | 4 | |a respiratory motion correction | |
| 650 | 4 | |a slice tracking | |
| 650 | 4 | |a subject-specific tracking factor | |
| 700 | 1 | |a Neji, Radhouene |e verfasserin |4 aut | |
| 700 | 1 | |a McElroy, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Nazir, Muhummad Sohaib |e verfasserin |4 aut | |
| 700 | 1 | |a Razavi, Reza |e verfasserin |4 aut | |
| 700 | 1 | |a Chiribiri, Amedeo |e verfasserin |4 aut | |
| 700 | 1 | |a Roujol, Sébastien |e verfasserin |4 aut | |
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