Immunohistochemical analysis for the diagnosis of solitary fibrous tumor/ hemangiopericytoma
The solitary fibrous tumor/ hemangiopericytoma (TFS/HP) is a rare mesenchymal extraaxial tumour. TFS/HP can sometimes be difficult to distinguish from other extra-axial tumors like meningioma, which can be clinically and radiologically indistinguishable. Molecular analysis with STAT6 (signal transducer and activator of transcription 6) nuclear expression or NAB2-STAT6 (NGFI-A binding protein 2) fusion is recommended to confirm the diagnosis. We present 3 cases, 2 women and 1 male, with pathological diagnosis of meningothelial meningioma in the first case; cases 2 and 3 with radiological suspicion of meningioma. The pathological review with molecular study certified the diagnosis of TFS/HP. For differential diagnosis between meningeal TFS/HP and meningioma, it is recommended to look for STAT6 expression as a first step, or NAB2-STAT6 fusion in order to confirm TFS/HP. The review of biopsy samples must be guaranteed in all patients, including those who were studied in Pathology Services Level 3.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:80 |
|---|---|
| Enthalten in: |
Medicina - 80(2020), 6 vom: 01., Seite 729-733 |
| Sprache: |
Spanisch |
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| Weiterer Titel: |
El análisis inmunohistoquímico para el diagnóstico del tumor fibroso solitario/ hemangiopericitoma |
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| Beteiligte Personen: |
González Roffo, Alejandra [VerfasserIn] |
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| Themen: |
Biomarkers, Tumor |
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| Anmerkungen: |
Date Completed 21.12.2020 Date Revised 31.05.2022 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM318204967 |
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| 245 | 1 | 0 | |a Immunohistochemical analysis for the diagnosis of solitary fibrous tumor/ hemangiopericytoma |
| 246 | 3 | 3 | |a El análisis inmunohistoquímico para el diagnóstico del tumor fibroso solitario/ hemangiopericitoma |
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| 500 | |a Date Revised 31.05.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The solitary fibrous tumor/ hemangiopericytoma (TFS/HP) is a rare mesenchymal extraaxial tumour. TFS/HP can sometimes be difficult to distinguish from other extra-axial tumors like meningioma, which can be clinically and radiologically indistinguishable. Molecular analysis with STAT6 (signal transducer and activator of transcription 6) nuclear expression or NAB2-STAT6 (NGFI-A binding protein 2) fusion is recommended to confirm the diagnosis. We present 3 cases, 2 women and 1 male, with pathological diagnosis of meningothelial meningioma in the first case; cases 2 and 3 with radiological suspicion of meningioma. The pathological review with molecular study certified the diagnosis of TFS/HP. For differential diagnosis between meningeal TFS/HP and meningioma, it is recommended to look for STAT6 expression as a first step, or NAB2-STAT6 fusion in order to confirm TFS/HP. The review of biopsy samples must be guaranteed in all patients, including those who were studied in Pathology Services Level 3 | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a STAT6 protein | |
| 650 | 4 | |a hemangiopericytoma | |
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| 650 | 4 | |a meningioma | |
| 650 | 4 | |a solitary fibrous tumor | |
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| 700 | 1 | |a Gómez Escalante, José I |e verfasserin |4 aut | |
| 700 | 1 | |a Banfi, Néstor |e verfasserin |4 aut | |
| 700 | 1 | |a Nocito, Ana Lía |e verfasserin |4 aut | |
| 700 | 1 | |a Báez, Alejandra |e verfasserin |4 aut | |
| 700 | 1 | |a Casas Parera, Ignacio |e verfasserin |4 aut | |
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