Animal Models in Polycystic Ovarian Syndrome
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved..
The pathogenesis of polycystic ovarian syndrome (PCOS) in women is poorly understood. With its varied endocrine and metabolic effects, it is unlikely a single genetic mutation or biological insult is the cause of the disease. Animals have been the proposed model for further studying the pathogenesis of PCOS and many modalities can be used to induce PCOS-like phenotypes in animals, most often with rodents. While there is not yet an animal model that perfectly recapitulates the classic PCOS phenotype in human women, many models allow for a better understanding of the complex disease process as well as possible treatments.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:64 |
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| Enthalten in: |
Clinical obstetrics and gynecology - 64(2021), 1 vom: 01. März, Seite 126-133 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dunn, Ariel J [VerfasserIn] |
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| Anmerkungen: |
Date Completed 15.10.2021 Date Revised 15.10.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1097/GRF.0000000000000580 |
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| funding: |
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NLM317969137 |
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| 520 | |a The pathogenesis of polycystic ovarian syndrome (PCOS) in women is poorly understood. With its varied endocrine and metabolic effects, it is unlikely a single genetic mutation or biological insult is the cause of the disease. Animals have been the proposed model for further studying the pathogenesis of PCOS and many modalities can be used to induce PCOS-like phenotypes in animals, most often with rodents. While there is not yet an animal model that perfectly recapitulates the classic PCOS phenotype in human women, many models allow for a better understanding of the complex disease process as well as possible treatments | ||
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