Paraneoplastic anti-gamma aminobutyric acid (GABA)B receptor antibody limbic encephalitis associated with small cell lung cancer presenting as new-onset status epilepticus : a case report
An 84-year-old man was admitted to our hospital with new-onset refractory status epilepticus of unclear etiology. On the third day, diffusion-weighted brain MRI demonstrated lesions in the right medial temporal and parietal lobes. As a CSF sample showed pleocytosis, paraneoplastic limbic encephalitis (PLE) associated with small cell lung cancer (SCLC) was suspected. The patient was also positive for anti-gamma aminobutyric acid (GABA)B receptor antibody in the CSF, which has recently been reported in elderly patients with SCLC-related PLE. Methylprednisolone pulse therapy ameliorated the symptoms. It is noteworthy that immune therapy often improves the symptoms of PLE with anti-GABAB receptor antibody, even though radical therapy for the lung cancer may be difficult.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:60 |
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| Enthalten in: |
Rinsho shinkeigaku = Clinical neurology - 60(2020), 12 vom: 26. Dez., Seite 869-873 |
| Sprache: |
Japanisch |
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| Beteiligte Personen: |
Akiyama, Natsuki [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 29.04.2021 Date Revised 29.04.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.5692/clinicalneurol.cn-001503 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM31796755X |
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| 500 | |a Date Revised 29.04.2021 | ||
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a An 84-year-old man was admitted to our hospital with new-onset refractory status epilepticus of unclear etiology. On the third day, diffusion-weighted brain MRI demonstrated lesions in the right medial temporal and parietal lobes. As a CSF sample showed pleocytosis, paraneoplastic limbic encephalitis (PLE) associated with small cell lung cancer (SCLC) was suspected. The patient was also positive for anti-gamma aminobutyric acid (GABA)B receptor antibody in the CSF, which has recently been reported in elderly patients with SCLC-related PLE. Methylprednisolone pulse therapy ameliorated the symptoms. It is noteworthy that immune therapy often improves the symptoms of PLE with anti-GABAB receptor antibody, even though radical therapy for the lung cancer may be difficult | ||
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| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a immunotherapy | |
| 650 | 4 | |a paraneoplastic limbic encephalitis | |
| 650 | 4 | |a small cell lung cancer | |
| 650 | 7 | |a Autoantibodies |2 NLM | |
| 650 | 7 | |a Receptors, GABA-B |2 NLM | |
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| 700 | 1 | |a Miwa, Yamato |e verfasserin |4 aut | |
| 700 | 1 | |a Umeda, Yoshitaka |e verfasserin |4 aut | |
| 700 | 1 | |a Tanaka, Keiko |e verfasserin |4 aut | |
| 700 | 1 | |a Oyake, Mutsuo |e verfasserin |4 aut | |
| 700 | 1 | |a Fujita, Nobuya |e verfasserin |4 aut | |
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