In utero pyrethroid pesticide exposure in relation to autism spectrum disorder (ASD) and other neurodevelopmental outcomes at 3 years in the MARBLES longitudinal cohort
Copyright © 2020 Elsevier Inc. All rights reserved..
BACKGROUND: We assessed the relationships between prenatal pyrethroid pesticide exposure and autism spectrum disorders (ASD) or non-typical development (non-TD) at 3 years.
METHODS: Participants were mother-child pairs (n = 201) in the MARBLES (Markers of Autism Risk in Babies-Learning Early Signs) cohort. Because familial recurrence risk is high, MARBLES enrolls pregnant women with a family history of ASD. Children from these pregnancies were clinically assessed at 3 years of age and classified into 3 outcome categories: ASD, typically developing (TD), or non-TD (neither TD or ASD). Repeated maternal second and third trimester urine samples were analyzed for pyrethroid metabolite 3-phenoxybenzoic acid (3-PBA). Multinomial logistic regression was used to obtain relative risk ratios (RRR) linking 3-PBA concentrations averaged across each trimester and over pregnancy with child's outcome: ASD or non-TD vs. TD. Models were adjusted for specific gravity, maternal pre-pregnancy BMI, prenatal vitamin use, birth year, home-ownership, and pregnancy concentrations of TCPy (3,5,6-trichloro-2-pyridinol, a metabolite of chlorpyrifos).
RESULTS: The median specific gravity corrected 3-PBA concentration of all samples was 1.46 ng/mL. Greater second trimester 3-PBA concentrations were associated with a relative risk ratio (RRR) for ASD of (RRR: 1.50 (95% CI 0.89 to 2.51), p = 0.12). There were no differences between non-TD and TD.
CONCLUSIONS: This study found no evidence for differences in 3-PBA comparing non-TD with TD. A modestly elevated RRR was found comparing second trimester urinary 3-PBA concentrations for ASD versus TD; however, the confidence interval was wide and hence, these findings cannot be considered definitive.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:194 |
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| Enthalten in: |
Environmental research - 194(2021) vom: 12. März, Seite 110495 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Barkoski, Jacqueline M [VerfasserIn] |
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| Links: |
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| Themen: |
Autism |
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| Anmerkungen: |
Date Completed 21.04.2021 Date Revised 02.03.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.envres.2020.110495 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM317872702 |
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| 100 | 1 | |a Barkoski, Jacqueline M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a In utero pyrethroid pesticide exposure in relation to autism spectrum disorder (ASD) and other neurodevelopmental outcomes at 3 years in the MARBLES longitudinal cohort |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Completed 21.04.2021 | ||
| 500 | |a Date Revised 02.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: We assessed the relationships between prenatal pyrethroid pesticide exposure and autism spectrum disorders (ASD) or non-typical development (non-TD) at 3 years | ||
| 520 | |a METHODS: Participants were mother-child pairs (n = 201) in the MARBLES (Markers of Autism Risk in Babies-Learning Early Signs) cohort. Because familial recurrence risk is high, MARBLES enrolls pregnant women with a family history of ASD. Children from these pregnancies were clinically assessed at 3 years of age and classified into 3 outcome categories: ASD, typically developing (TD), or non-TD (neither TD or ASD). Repeated maternal second and third trimester urine samples were analyzed for pyrethroid metabolite 3-phenoxybenzoic acid (3-PBA). Multinomial logistic regression was used to obtain relative risk ratios (RRR) linking 3-PBA concentrations averaged across each trimester and over pregnancy with child's outcome: ASD or non-TD vs. TD. Models were adjusted for specific gravity, maternal pre-pregnancy BMI, prenatal vitamin use, birth year, home-ownership, and pregnancy concentrations of TCPy (3,5,6-trichloro-2-pyridinol, a metabolite of chlorpyrifos) | ||
| 520 | |a RESULTS: The median specific gravity corrected 3-PBA concentration of all samples was 1.46 ng/mL. Greater second trimester 3-PBA concentrations were associated with a relative risk ratio (RRR) for ASD of (RRR: 1.50 (95% CI 0.89 to 2.51), p = 0.12). There were no differences between non-TD and TD | ||
| 520 | |a CONCLUSIONS: This study found no evidence for differences in 3-PBA comparing non-TD with TD. A modestly elevated RRR was found comparing second trimester urinary 3-PBA concentrations for ASD versus TD; however, the confidence interval was wide and hence, these findings cannot be considered definitive | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Autism | |
| 650 | 4 | |a MARBLES | |
| 650 | 4 | |a Neurodevelopment | |
| 650 | 4 | |a Pesticide | |
| 650 | 4 | |a Pregnancy | |
| 650 | 4 | |a Pyrethroid | |
| 650 | 7 | |a Pesticides |2 NLM | |
| 650 | 7 | |a Pyrethrins |2 NLM | |
| 650 | 7 | |a Calcium Carbonate |2 NLM | |
| 650 | 7 | |a H0G9379FGK |2 NLM | |
| 700 | 1 | |a Philippat, Claire |e verfasserin |4 aut | |
| 700 | 1 | |a Tancredi, Daniel |e verfasserin |4 aut | |
| 700 | 1 | |a Schmidt, Rebecca J |e verfasserin |4 aut | |
| 700 | 1 | |a Ozonoff, Sally |e verfasserin |4 aut | |
| 700 | 1 | |a Barr, Dana Boyd |e verfasserin |4 aut | |
| 700 | 1 | |a Elms, William |e verfasserin |4 aut | |
| 700 | 1 | |a Bennett, Deborah H |e verfasserin |4 aut | |
| 700 | 1 | |a Hertz-Picciotto, Irva |e verfasserin |4 aut | |
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