Chemical Protein Synthesis : Advances, Challenges, and Outlooks
Contemporary chemical protein synthesis has been dramatically advanced over the past few decades, which has enabled chemists to reach the landscape of synthetic biomacromolecules. Chemical synthesis can produce synthetic proteins with precisely controlled structures which are difficult or impossible to obtain via gene expression systems. Herein, we summarize the key enabling ligation technologies, major strategic developments, and some selected representative applications of synthetic proteins and provide an outlook for future development.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2020 |
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| Enthalten in: |
Journal of the American Chemical Society - (2020) vom: 19. Nov. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tan, Yi [VerfasserIn] |
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| Links: |
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Date Revised 22.02.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1021/jacs.0c09664 |
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| funding: |
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NLM317785915 |
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| 520 | |a Contemporary chemical protein synthesis has been dramatically advanced over the past few decades, which has enabled chemists to reach the landscape of synthetic biomacromolecules. Chemical synthesis can produce synthetic proteins with precisely controlled structures which are difficult or impossible to obtain via gene expression systems. Herein, we summarize the key enabling ligation technologies, major strategic developments, and some selected representative applications of synthetic proteins and provide an outlook for future development | ||
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