Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19
Long pentraxin 3 (PTX3) is an essential component of humoral innate immunity, involved in resistance to selected pathogens and in the regulation of inflammation1-3. The present study was designed to assess the presence and significance of PTX3 in Coronavirus Disease 2019 (COVID-19)4-7. RNA-sequencing analysis of peripheral blood mononuclear cells, single-cell bioinformatics analysis and immunohistochemistry of lung autopsy samples revealed that myelomonocytic cells and endothelial cells express high levels of PTX3 in patients with COVID-19. Increased plasma concentrations of PTX3 were detected in 96 patients with COVID-19. PTX3 emerged as a strong independent predictor of 28-d mortality in multivariable analysis, better than conventional markers of inflammation, in hospitalized patients with COVID-19. The prognostic significance of PTX3 abundance for mortality was confirmed in a second independent cohort (54 patients). Thus, circulating and lung myelomonocytic cells and endothelial cells are a major source of PTX3, and PTX3 plasma concentration can serve as an independent strong prognostic indicator of short-term mortality in COVID-19.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
Nature immunology - 22(2021), 1 vom: 18. Jan., Seite 19-24 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Brunetta, Enrico [VerfasserIn] |
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| Links: |
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| Themen: |
148591-49-5 |
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| Anmerkungen: |
Date Completed 25.01.2021 Date Revised 22.04.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41590-020-00832-x |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM317760955 |
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| 245 | 1 | 0 | |a Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19 |
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| 500 | |a Date Revised 22.04.2022 | ||
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| 520 | |a Long pentraxin 3 (PTX3) is an essential component of humoral innate immunity, involved in resistance to selected pathogens and in the regulation of inflammation1-3. The present study was designed to assess the presence and significance of PTX3 in Coronavirus Disease 2019 (COVID-19)4-7. RNA-sequencing analysis of peripheral blood mononuclear cells, single-cell bioinformatics analysis and immunohistochemistry of lung autopsy samples revealed that myelomonocytic cells and endothelial cells express high levels of PTX3 in patients with COVID-19. Increased plasma concentrations of PTX3 were detected in 96 patients with COVID-19. PTX3 emerged as a strong independent predictor of 28-d mortality in multivariable analysis, better than conventional markers of inflammation, in hospitalized patients with COVID-19. The prognostic significance of PTX3 abundance for mortality was confirmed in a second independent cohort (54 patients). Thus, circulating and lung myelomonocytic cells and endothelial cells are a major source of PTX3, and PTX3 plasma concentration can serve as an independent strong prognostic indicator of short-term mortality in COVID-19 | ||
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| 700 | 1 | |a Gritti, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Protti, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Mapelli, Sarah N |e verfasserin |4 aut | |
| 700 | 1 | |a Bonovas, Stefanos |e verfasserin |4 aut | |
| 700 | 1 | |a Piovani, Daniele |e verfasserin |4 aut | |
| 700 | 1 | |a Leone, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a My, Ilaria |e verfasserin |4 aut | |
| 700 | 1 | |a Zanon, Veronica |e verfasserin |4 aut | |
| 700 | 1 | |a Spata, Gianmarco |e verfasserin |4 aut | |
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