Richard Dickerson, Molecular Clocks, and Rates of Protein Evolution
Proteins approximately behave as molecular clocks, accumulating amino acid replacements at a more or less constant rate. Nonetheless, each protein displays a characteristic rate of evolution: whereas some proteins remain largely unaltered over large periods of time, others can rapidly accumulate amino acid replacements. An article by Richard Dickerson, published in the first issue of the Journal of Molecular Evolution (J Mol Evol 1:26-45, 1971), described the first analysis in which the rates of evolution of many proteins were compared, and the differences were interpreted in the light of their function. When comparing the sequences of fibrinopeptides, hemoglobin, and cytochrome c of different species, he observed a linear relationship between the number of amino acid replacements and divergence time. Remarkably, fibrinopeptides had evolved fast, cytochrome c had evolved slowly, and hemoglobin exhibited an intermediate rate of evolution. As the Journal of Molecular Evolution celebrates its 50th anniversary, I highlight this landmark article and reflect on its impact on the field of Molecular Evolution.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:89 |
---|---|
Enthalten in: |
Journal of molecular evolution - 89(2021), 3 vom: 17. Apr., Seite 122-126 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Alvarez-Ponce, David [VerfasserIn] |
---|
Links: |
---|
Themen: |
Amino Acids |
---|
Anmerkungen: |
Date Completed 17.09.2021 Date Revised 17.09.2021 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1007/s00239-020-09973-x |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM317725319 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM317725319 | ||
003 | DE-627 | ||
005 | 20231225163854.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2021 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1007/s00239-020-09973-x |2 doi | |
028 | 5 | 2 | |a pubmed24n1059.xml |
035 | |a (DE-627)NLM317725319 | ||
035 | |a (NLM)33205299 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Alvarez-Ponce, David |e verfasserin |4 aut | |
245 | 1 | 0 | |a Richard Dickerson, Molecular Clocks, and Rates of Protein Evolution |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 17.09.2021 | ||
500 | |a Date Revised 17.09.2021 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Proteins approximately behave as molecular clocks, accumulating amino acid replacements at a more or less constant rate. Nonetheless, each protein displays a characteristic rate of evolution: whereas some proteins remain largely unaltered over large periods of time, others can rapidly accumulate amino acid replacements. An article by Richard Dickerson, published in the first issue of the Journal of Molecular Evolution (J Mol Evol 1:26-45, 1971), described the first analysis in which the rates of evolution of many proteins were compared, and the differences were interpreted in the light of their function. When comparing the sequences of fibrinopeptides, hemoglobin, and cytochrome c of different species, he observed a linear relationship between the number of amino acid replacements and divergence time. Remarkably, fibrinopeptides had evolved fast, cytochrome c had evolved slowly, and hemoglobin exhibited an intermediate rate of evolution. As the Journal of Molecular Evolution celebrates its 50th anniversary, I highlight this landmark article and reflect on its impact on the field of Molecular Evolution | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
650 | 4 | |a Evolutionary rate | |
650 | 4 | |a Molecular clock | |
650 | 4 | |a Richard Dickerson | |
650 | 7 | |a Amino Acids |2 NLM | |
650 | 7 | |a Hemoglobins |2 NLM | |
773 | 0 | 8 | |i Enthalten in |t Journal of molecular evolution |d 1971 |g 89(2021), 3 vom: 17. Apr., Seite 122-126 |w (DE-627)NLM000019666 |x 1432-1432 |7 nnns |
773 | 1 | 8 | |g volume:89 |g year:2021 |g number:3 |g day:17 |g month:04 |g pages:122-126 |
856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00239-020-09973-x |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 89 |j 2021 |e 3 |b 17 |c 04 |h 122-126 |