Bioengineering of Virus-like Particles for the Prevention or Treatment of Allergic Diseases

Copyright © 2021 The Korean Academy of Asthma, Allergy and Clinical Immunology · The Korean Academy of Pediatric Allergy and Respiratory Disease..

Recent findings on the mechanism of allergen-specific immunotherapy (AIT) have revisited the role of immunoglobulin G (IgG) as the development of specific blocking IgG antibodies appeared critical for the successful suppression of T-helper 2 (Th2)-biased allergic responses. Consequently, any form of molecular AIT-promoting potent allergen-specific neutralizing antibodies would be preferred to conventional administration of allergen extracts. The potent immunogenicity of virus-like particles (VLPs) could be harnessed for that purpose. The particle size (20-200 nm) optimizes uptake by antigen-presenting cells as well as lymphatic trafficking. Moreover, the display of antigens in repetitive arrays promotes potent B cell activation for the development of sustained antibody responses. The presentation of self-antigens on the particle surface was even capable to break B cell tolerance. In this review, we describe the immunomodulatory properties of the 3 VLP-based strategies designed so far for the treatment of allergic disease: VLP packaged with CpG motifs as well as chimeric particles displaying pro-Th2/Th2 cytokines or allergens (full-length or B cell epitopes).

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:13

Enthalten in:

Allergy, asthma & immunology research - 13(2021), 1 vom: 03. Jan., Seite 23-41

Sprache:

Englisch

Beteiligte Personen:

Pechsrichuang, Phornsiri [VerfasserIn]
Namwongnao, Supannika [VerfasserIn]
Jacquet, Alain [VerfasserIn]

Links:

Volltext

Themen:

Allergen
Autoantibodies
Blocking antibodies
CpG motif
Journal Article
Nanoparticles
Review

Anmerkungen:

Date Revised 01.01.2021

published: Print

Citation Status PubMed-not-MEDLINE

doi:

10.4168/aair.2021.13.1.23

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM317590731