The Effect of Aging Physiology on Critical Care
Copyright © 2020 Elsevier Inc. All rights reserved..
Older patients experience a decline in their physiologic reserves as well as chronic low-grade inflammation named "inflammaging." Both of these contribute significantly to aging-related factors that alter the acute, subacute, and chronic response of these patients to critical illness, such as sepsis. Unfortunately, this altered response to stressors can lead to chronic critical illness followed by dismal outcomes and death. The primary goal of this review is to briefly highlight age-specific changes in physiologic systems majorly affected in critical illness, especially because it pertains to sepsis and trauma, which can lead to chronic critical illness and describe implications in clinical management.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:37 |
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| Enthalten in: |
Critical care clinics - 37(2021), 1 vom: 07. Jan., Seite 135-150 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Darden, Dijoia B [VerfasserIn] |
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| Links: |
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| Themen: |
Aging |
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| Anmerkungen: |
Date Completed 18.08.2021 Date Revised 19.12.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ccc.2020.08.006 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM317581732 |
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| 520 | |a Older patients experience a decline in their physiologic reserves as well as chronic low-grade inflammation named "inflammaging." Both of these contribute significantly to aging-related factors that alter the acute, subacute, and chronic response of these patients to critical illness, such as sepsis. Unfortunately, this altered response to stressors can lead to chronic critical illness followed by dismal outcomes and death. The primary goal of this review is to briefly highlight age-specific changes in physiologic systems majorly affected in critical illness, especially because it pertains to sepsis and trauma, which can lead to chronic critical illness and describe implications in clinical management | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Aging | |
| 650 | 4 | |a Chronic critical illness | |
| 650 | 4 | |a Critical care | |
| 650 | 4 | |a Geriatrics | |
| 650 | 4 | |a Physiology | |
| 650 | 4 | |a Sepsis | |
| 650 | 4 | |a Trauma | |
| 700 | 1 | |a Moore, Frederick A |e verfasserin |4 aut | |
| 700 | 1 | |a Brakenridge, Scott C |e verfasserin |4 aut | |
| 700 | 1 | |a Navarro, Eduardo B |e verfasserin |4 aut | |
| 700 | 1 | |a Anton, Stephen D |e verfasserin |4 aut | |
| 700 | 1 | |a Leeuwenburgh, Christiaan |e verfasserin |4 aut | |
| 700 | 1 | |a Moldawer, Lyle L |e verfasserin |4 aut | |
| 700 | 1 | |a Mohr, Alicia M |e verfasserin |4 aut | |
| 700 | 1 | |a Efron, Philip A |e verfasserin |4 aut | |
| 700 | 1 | |a Mankowski, Robert T |e verfasserin |4 aut | |
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