Clinical outcomes of infection-related hospitalization in incident peritoneal dialysis patients
BACKGROUND: Infection is the second leading cause of death in patients undergoing long-term dialysis. Peritoneal dialysis (PD) is associated with an increased risk of infection-related hospitalization (IRH) when compared with hemodialysis. In this study, we investigated the influence of IRH on clinical outcomes in incident PD patients.
METHODS: In total, 583 incident PD patients were selected from the Clinical Research Center Registry for End-Stage Renal Disease, a nationwide multicenter prospective observational cohort study in Korea. Incident PD patients who had been hospitalized for infection-related diseases were defined as the IRH group. The primary outcome was all-cause mortality and the secondary outcome was technical failure. The median follow-up period was 29 months.
RESULTS: Seventy-three PD patients (12.5%) were categorized in the IRH group. Multivariable logistic regression analysis showed that diabetes mellitus was a significant independent predictor for IRH (odds ratio, 2.43; 95% confidence interval [CI], 1.12 to 5.29; P = 0.007). The most common causes of IRH were peritonitis (63.0%) and respiratory tract infection (9.6%). Multivariable Cox proportional hazard model analysis showed that IRH was a significant independent risk factor for all-cause mortality (hazard ratio [HR], 2.51; 95% CI, 1.12 to 5.62; P = 0.026) and for the technical failure of PD (HR, 3.23; 95% CI, 1.90 to 5.51; P < 0.001).
CONCLUSION: Our data showed that after initiation of PD, IRH was significantly associated with higher risk of all-cause mortality and technical failure.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:39 |
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| Enthalten in: |
Kidney research and clinical practice - 39(2020), 4 vom: 31. Dez., Seite 460-468 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jeon, Youngdong [VerfasserIn] |
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| Links: |
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| Themen: |
Hospitalization |
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| Anmerkungen: |
Date Revised 19.04.2022 published: Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.23876/j.krcp.20.069 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM317517341 |
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| 500 | |a Date Revised 19.04.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a BACKGROUND: Infection is the second leading cause of death in patients undergoing long-term dialysis. Peritoneal dialysis (PD) is associated with an increased risk of infection-related hospitalization (IRH) when compared with hemodialysis. In this study, we investigated the influence of IRH on clinical outcomes in incident PD patients | ||
| 520 | |a METHODS: In total, 583 incident PD patients were selected from the Clinical Research Center Registry for End-Stage Renal Disease, a nationwide multicenter prospective observational cohort study in Korea. Incident PD patients who had been hospitalized for infection-related diseases were defined as the IRH group. The primary outcome was all-cause mortality and the secondary outcome was technical failure. The median follow-up period was 29 months | ||
| 520 | |a RESULTS: Seventy-three PD patients (12.5%) were categorized in the IRH group. Multivariable logistic regression analysis showed that diabetes mellitus was a significant independent predictor for IRH (odds ratio, 2.43; 95% confidence interval [CI], 1.12 to 5.29; P = 0.007). The most common causes of IRH were peritonitis (63.0%) and respiratory tract infection (9.6%). Multivariable Cox proportional hazard model analysis showed that IRH was a significant independent risk factor for all-cause mortality (hazard ratio [HR], 2.51; 95% CI, 1.12 to 5.62; P = 0.026) and for the technical failure of PD (HR, 3.23; 95% CI, 1.90 to 5.51; P < 0.001) | ||
| 520 | |a CONCLUSION: Our data showed that after initiation of PD, IRH was significantly associated with higher risk of all-cause mortality and technical failure | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Hospitalization | |
| 650 | 4 | |a Infections | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Peritoneal dialysis | |
| 650 | 4 | |a Peritonitis | |
| 700 | 1 | |a Kim, Hyung Duk |e verfasserin |4 aut | |
| 700 | 1 | |a Hong, Yu Ah |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Hyung Wook |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Chul Woo |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Yoon-Kyung |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Yong Kyun |e verfasserin |4 aut | |
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