Association Between Plasma Lipoprotein-Associated Phospholipase A2 and Plaque Vulnerability in TIA Patients With Unilateral Middle Cerebral Artery Stenosis

Copyright © 2020 Qin, Qian, Luo, Li, Wang, Jiang, Zhang, Liu, Xiao, Zhang, Diao and Zhao..

Background: Plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) has emerged as a novel biomarker for coronary atherosclerosis. However, the association between Lp-PLA2 and plaque vulnerability in atherosclerosis of cervicocerebral arteries remains poorly defined, especially for intracranial atherosclerotic stenosis (ICAS). We aimed to investigate the association between Lp-PLA2 and plaque vulnerability in transient ischemic attack (TIA) patients with unilateral middle cerebral artery stenoses (MCAs). Methods: In this study, a total of 207 patients were enrolled from April 2017 to April 2020. Clinical data were collected, and MCA plaques were examined with high-resolution magnetic resonance imaging (HRMRI). Baseline characteristics of patients were collected during hospitalization. Statistical comparisons were performed using Pearson's chi-squared test, Mann-Whitney U test, and the Breslow-Day/Tarone's test for the determination of heterogeneity in different age strata. Multivariate binary logistic analysis was used to investigate the potential independent predictors that were highly correlated to plaque vulnerability. Results: The results showed that a high Lp-PLA2 level (>221 ng/ml) was associated with plaque vulnerability in TIA patients with unilateral MCAs. High Lp-PLA2 was independently associated with plaque vulnerability in patients ≤ 60 years old [multivariate adjusted odds ratio (OR) = 9.854; 95% CI, 2.458-39.501] but not in patients >60 years old (multivariate adjusted OR = 1.901; 95% CI, 0.640-5.650). Predictors of plaque vulnerability in different age strata were also different. Conclusion: Lp-PLA2 levels may be correlated to plaque vulnerability in TIA patients with unilateral MCAs and might be a diagnostic biomarker for plaque vulnerability in this kind of patients, especially for ones aged ≤ 60 years old.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:11

Enthalten in:

Frontiers in neurology - 11(2020) vom: 27., Seite 574036

Sprache:

Englisch

Beteiligte Personen:

Qin, Yiren [VerfasserIn]
Qian, Xiaoyan [VerfasserIn]
Luo, Xue [VerfasserIn]
Li, Yuanfang [VerfasserIn]
Wang, Dapeng [VerfasserIn]
Jiang, Jianhua [VerfasserIn]
Zhang, Quanquan [VerfasserIn]
Liu, Meirong [VerfasserIn]
Xiao, Junhua [VerfasserIn]
Zhang, Yan [VerfasserIn]
Diao, Shanshan [VerfasserIn]
Zhao, Hongru [VerfasserIn]

Links:

Volltext

Themen:

HRMRI
ICAs
Journal Article
Lp-PLA2
Middle cerebral artery
Transient ischemic attack

Anmerkungen:

Date Revised 13.11.2020

published: Electronic-eCollection

Citation Status PubMed-not-MEDLINE

doi:

10.3389/fneur.2020.574036

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM31745689X