Higher baseline lipid levels amplify the benefit of secondary prevention therapy with statins in Chinese patients with acute coronary syndrome

OBJECTIVE: Statins are recommended as the first-line treatments for reducing the risk of major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS). The present study aimed to establish the baseline lipid levels associated with the greatest benefit from statin therapy in this population.

METHODS: The study used a retrospective cohort methodology. In total, 636 patients with ACS were enrolled at Shaanxi Provincial People's Hospital from 2011 to 2013. Participants were divided into four groups (group 1, hyperlipidemia with inconsistent statin use; group 2, no hyperlipidemia with inconsistent statin use; group 3, no hyperlipidemia with consistent statin use; and group 4, hyperlipidemia with consistent statin use).

RESULTS: Patients in groups 3 (hazard ratio [HR] = 0.49, 95% confidence interval [CI] = 0.29-0.82) and 4 (HR = 0.21, 95% CI = 0.10-0.45) had lower risks of MACE than those in group 1. In subgroup analysis, patients in group 4 had a lower risk of MACE than those in group 3 (adjusted HR = 0.43, 95% CI = 0.21-0.89).

CONCLUSION: Sustained statin therapy is associated with a lower risk of adverse outcomes in patients with ACS, especially in those with higher baseline lipid levels.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:48

Enthalten in:

The Journal of international medical research - 48(2020), 11 vom: 02. Nov., Seite 300060520965848

Sprache:

Englisch

Beteiligte Personen:

Zhu, Ling [VerfasserIn]
Liu, Ying [VerfasserIn]
Zhang, Wei [VerfasserIn]
Zhang, Zhu [VerfasserIn]
Zhou, Liqin [VerfasserIn]
Zhang, Hong [VerfasserIn]
Zhang, Yong [VerfasserIn]
Liu, Fuqiang [VerfasserIn]
Liu, Peng [VerfasserIn]
Liu, Zhongwei [VerfasserIn]
Wang, Junkui [VerfasserIn]

Links:

Volltext

Themen:

Acute coronary syndrome
Chinese
Cohort study
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hyperlipidemia
Journal Article
Lipid
Lipids
Major adverse cardiovascular events
Statin

Anmerkungen:

Date Completed 14.05.2021

Date Revised 14.05.2021

published: Print

Citation Status MEDLINE

doi:

10.1177/0300060520965848

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM317069934