Age-related differences of oncological outcomes in primary extremity soft tissue sarcoma : a multistate model including 6260 patients

Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved..

PURPOSE: No studies extensively compared the young adults (YA, 18-39 years), middle-aged (40-69 years), and elderly (≥70 years) population with primary high-grade extremity soft tissue sarcoma (eSTS). This study aimed to determine whether the known effect of age on overall survival (OS) and disease progression can be explained by differences in tumour characteristics and treatment protocol among the YA, middle-aged and elderly population in patients with primary high-grade eSTS treated with curative intent.

METHODS: In this retrospective multicentre study, inclusion criteria were patients with primary high-grade eSTS of 18 years and older, surgically treated with curative intent between 2000 and 2016. Cox proportional hazard models and a multistate model were used to determine the association of age on OS and disease progression.

RESULTS: A total of 6260 patients were included in this study. YA presented more often after 'whoops'-surgery or for reresection due to residual disease, and with more deep-seated tumours. Elderly patients presented more often with grade III and larger (≥10 cm) tumours. After adjustment for the imbalance in tumour and treatment characteristics the hazard ratio for OS of the middle-aged population is 1.47 (95% confidence interval [CI]: 1.23-1.76) and 3.13 (95% CI: 2.59-3.78) in the elderly population, compared with YA.

DISCUSSION: The effect of age on OS could only partially be explained by the imbalance in the tumour characteristics and treatment variables. The threefold higher risk of elderly could, at least partially, be explained by a higher other-cause mortality. The results might also be explained by a different tumour behaviour or suboptimal treatment in elderly compared with the younger population.

Errataetall:

ErratumIn: Eur J Cancer. 2022 Feb;162:247-249. - PMID 34980501

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:141

Enthalten in:

European journal of cancer (Oxford, England : 1990) - 141(2020) vom: 01. Dez., Seite 128-136

Sprache:

Englisch

Beteiligte Personen:

Acem, Ibtissam [VerfasserIn]
Verhoef, Cornelis [VerfasserIn]
Rueten-Budde, Anja J [VerfasserIn]
Grünhagen, Dirk J [VerfasserIn]
van Houdt, Winan J [VerfasserIn]
van de Sande, Michiel A J [VerfasserIn]
PERSARC study group [VerfasserIn]
Aston, Will [Sonstige Person]
Bonenkamp, Han [Sonstige Person]
Desar, Ingrid M E [Sonstige Person]
Ferguson, Peter C [Sonstige Person]
Fiocco, Marta [Sonstige Person]
Gelderblom, Hans [Sonstige Person]
van Ginkel, Robert J [Sonstige Person]
van der Graaf, Winette [Sonstige Person]
Griffin, Anthony M [Sonstige Person]
Haas, Rick L [Sonstige Person]
van der Hage, Jos A [Sonstige Person]
Hayes, Andrew J [Sonstige Person]
Jeys, Lee M [Sonstige Person]
Keller, Johnny [Sonstige Person]
Laitinen, Minna K [Sonstige Person]
Leithner, Andreas [Sonstige Person]
Maretty-Kongstad, Katja [Sonstige Person]
Ozaki, Toshifumi [Sonstige Person]
Pollock, Rob [Sonstige Person]
van Praag, Veroniek M [Sonstige Person]
Smith, Myles J [Sonstige Person]
Smolle, Maria A [Sonstige Person]
Styring, Emelie [Sonstige Person]
Szkandera, Joanna [Sonstige Person]
Tanaka, Kazuhiro [Sonstige Person]
Tunn, Per-Ulf [Sonstige Person]
Willegger, Madeleine [Sonstige Person]
Windhager, Reinard [Sonstige Person]
Wunder, Jay S [Sonstige Person]
Zaikova, Olga [Sonstige Person]

Links:

Volltext

Themen:

Adolescents and young adults
Elderly
Extremities
Journal Article
Metastasis
Middle-aged
Multicenter Study
Recurrence
Soft tissue sarcoma
Survival

Anmerkungen:

Date Completed 19.02.2021

Date Revised 04.01.2022

published: Print-Electronic

ErratumIn: Eur J Cancer. 2022 Feb;162:247-249. - PMID 34980501

Citation Status MEDLINE

doi:

10.1016/j.ejca.2020.09.021

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM317059254