Oleanolic acid protects against mast cell-mediated allergic responses by suppressing Akt/NF-κB and STAT1 activation

Copyright © 2020. Published by Elsevier GmbH..

BACKGROUND: Oleanolic acid (OA) is an active compound found in a variety of medicinal herbs and plants. Though OA has been widely attributed with a variety of biological activities, studies focused on its anti-allergic inflammation properties are insufficient.

PURPOSE: Given the rapid increase in allergic diseases and the lack of fundamental treatment options, this study aimed to find a safe and effective therapy for allergic disorders.

METHODS: We evaluated the inhibitory effect of OA on allergic inflammatory response and the possible mechanisms underlying the effect using phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated human mast cell (HMC)-1, and a mouse model of compound 48/80-induced anaphylactic shock.

RESULTS: OA suppressed pro-inflammatory cytokine expressions in PMACI-induced HMC-1 cells by inhibiting activation of the Akt, p38 mitogen-activated protein kinase (MAPK), nuclear factor-κB (NF-κB), and signal transducer and activator of transcription (STAT) 1 signaling pathways. Moreover, OA showed a protective effect against compound 48/80-induced anaphylactic shock through inhibition of histamine release and immunoglobulin E level via regulation of NF-κB and STAT1 activation.

CONCLUSION: The results showed that OA suppressed mast cell-mediated allergic response by transcriptional regulation. We suggest that OA has potential effect against allergic inflammatory disorders, including anaphylaxis, and might be a useful therapeutic agent for allergic disease.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:80

Enthalten in:

Phytomedicine : international journal of phytotherapy and phytopharmacology - 80(2021) vom: 01. Jan., Seite 153340

Sprache:

Englisch

Beteiligte Personen:

Kang, Yun-Mi [VerfasserIn]
Lee, Minho [VerfasserIn]
An, Hyo-Jin [VerfasserIn]

Links:

Volltext

Themen:

20839-06-9
37H9VM9WZL
4091-50-3
6SMK8R7TGJ
Allergic responses
Anaphylaxis
Anti-Allergic Agents
Calcimycin
Cytokines
EC 2.7.11.1
EC 2.7.11.24
Inflammation Mediators
Journal Article
Mast cell
NF-κB
NF-kappa B
Oleanolic Acid
Oleanolic acid
P-Methoxy-N-methylphenethylamine
P38 Mitogen-Activated Protein Kinases
Phorbol Esters
Phorbol-12-myristate
Proto-Oncogene Proteins c-akt
STAT1
STAT1 Transcription Factor
STAT1 protein, human

Anmerkungen:

Date Completed 28.12.2020

Date Revised 26.02.2024

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.phymed.2020.153340

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM316989207