No effect of prior Dengue virus 1 infection in mouse dams on long-term behavioral profiles in offspring infected with Zika virus during gestation

Copyright © 2020 Elsevier B.V. All rights reserved..

Zika virus (ZIKV) is a mosquito-borne Flavivirus structurally and antigenically related to Dengue virus (DENV). Zika virus has been associated with congenital anomalies and most ZIKV outbreaks have occurred in endemic areas of DENV. The present study investigated the effects of prior DENV serotype 1 (DENV1) immunity in immunocompetent female Swiss mice on gestational ZIKV infection in offspring. Physical/reflex development, locomotor activity, anxiety, visual acuity, and brain-derived neurotrophic factor (BDNF) levels were evaluated in offspring during infancy and adolescence. Anti-DENV1 and anti-ZIKV antibodies were detected in sera of the progenitors, whereas no ZIKV genomes were detected in the offspring brain. Pups from dams with only DENV1 immunity presented alterations of physical/reflex development. Pups from all infected dams exhibited time-related impairments in locomotor activity and anxiolytic-like behavior. Offspring from DENV/ZIKV-infected dams exhibited impairments in visual acuity during infancy but not during adolescence, which was consistent with morphometric analysis of the optic nerve. Pups from DENV1-, ZIKV-, and DENV/ZIKV-infected dams exhibited a decrease in BDNF levels during infancy and an increase during adolescence in distinct brain regions. In summary, we found no influence of prior DENV1 immunity on gestational ZIKV infection in offspring, with the exception of alterations of early visual parameters, and an increase in BDNF levels in the hippocampus during adolescence.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:739

Enthalten in:

Neuroscience letters - 739(2020) vom: 20. Nov., Seite 135448

Sprache:

Englisch

Beteiligte Personen:

Costa, Karla Cristinne Mancini [VerfasserIn]
Brancaglion, Gustavo Andrade [VerfasserIn]
Almeida, Carolina Aparecida de Faria [VerfasserIn]
de Amorim, Gabriel Estevam Santos [VerfasserIn]
Veloso, Luciana Lopes [VerfasserIn]
Lião, Lucas da Silva [VerfasserIn]
de Souza, Gabriel Augusto Pires [VerfasserIn]
Pinheiro, Bruna Pereira [VerfasserIn]
Ângelo, Marilene Lopes [VerfasserIn]
Ruginsk, Silvia Graciela [VerfasserIn]
Brandão, Wesley Nogueira [VerfasserIn]
Marcourakis, Tania [VerfasserIn]
Ceron, Carla Speroni [VerfasserIn]
Coelho, Luiz Felipe Leomil [VerfasserIn]
Torres, Larissa Helena [VerfasserIn]

Links:

Volltext

Themen:

Anxiety
BDNF
Bdnf protein, mouse
Behavior
Brain-Derived Neurotrophic Factor
Dengue virus 1
Development
Journal Article
Research Support, Non-U.S. Gov't
Zika virus

Anmerkungen:

Date Completed 30.04.2021

Date Revised 30.04.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.neulet.2020.135448

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM316982970