Beyond Mohs surgery and excisions : A focused review of treatment options for subtypes of basal cell carcinoma

© 2020 Wiley Periodicals LLC..

Basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer. It originates from undifferentiated cells in the basal cell layer of the epidermis or from the outer root sheath of the hair follicle. The most important factor in development of BCC is ultraviolet radiation. Surgery is considered the gold standard of treatment for BCC. However, nonsurgical options are available for individuals who are unsuitable for surgery. The purpose of this review is to summarize the efficacy and indications of alternative, nonsurgical treatments that can be used in the management of BCC. An extensive literature review was performed for the nonsurgical options for the treatment of BCC. Resources searched included PubMed and Google Scholars, limited to the years 1995 to 2020. Key words searched included BCC, destructive methods, photodynamic therapy (PDT), radiotherapy, topical medication, laser, hedgehog pathway inhibitors (HPIs). The most relevant results such as systematic reviews, randomized controlled trials, or comparative studies were selected to provide a summary for the most common nonsurgical methods used for treating BCC. Effective nonsurgical treatments for BCC include destructive methods (eg, curettage alone, cryosurgery, or electrodessication), PDT, topical medications, radiotherapy, laser, and HPIs. Nonsurgical therapeutic alternatives are safe and effective for the treatment of BCC. Factors such as tumor location, size, and histopathological subtype should be taken into consideration when selecting optimal treatment. In addition to clinical factors, cosmetic results and patient preference should be considered.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:34

Enthalten in:

Dermatologic therapy - 34(2021), 1 vom: 16. Jan., Seite e14476

Sprache:

Englisch

Beteiligte Personen:

Altun, Ece [VerfasserIn]
Schwartzman, Gabrielle [VerfasserIn]
Cartron, Alexander M [VerfasserIn]
Khachemoune, Amor [VerfasserIn]

Links:

Volltext

Themen:

Basal cell carcinoma
Destructive methods
Hedgehog Proteins
Hedgehog pathway inhibitors
Journal Article
Laser
Photodynamic therapy
Radiotherapy
Review
Topical medication

Anmerkungen:

Date Completed 24.05.2021

Date Revised 24.05.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1111/dth.14476

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM316943045