Beyond tradition and convention : benefits of non-traditional model organisms in cancer research

Traditional laboratory model organisms are indispensable for cancer research and have provided insight into numerous mechanisms that contribute to cancer development and progression in humans. However, these models do have some limitations, most notably related to successful drug translation, because traditional model organisms are often short-lived, small-bodied, genetically homogeneous, often immunocompromised, are not exposed to natural environments shared with humans, and usually do not develop cancer spontaneously. We propose that assimilating information from a variety of long-lived, large, genetically diverse, and immunocompetent species that live in natural environments and do develop cancer spontaneously (or do not develop cancer at all) will lead to a more comprehensive understanding of human cancers. These non-traditional model organisms can also serve as sentinels for environmental risk factors that contribute to human cancers. Ultimately, expanding the range of animal models that can be used to study cancer will lead to improved insights into cancer development, progression and metastasis, tumor microenvironment, as well as improved therapies and diagnostics, and will consequently reduce the negative impacts of the wide variety of cancers afflicting humans overall.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:40

Enthalten in:

Cancer metastasis reviews - 40(2021), 1 vom: 28. März, Seite 47-69

Sprache:

Englisch

Beteiligte Personen:

Harman, Rebecca M [VerfasserIn]
Das, Sanjna P [VerfasserIn]
Bartlett, Arianna P [VerfasserIn]
Rauner, Gat [VerfasserIn]
Donahue, Leanne R [VerfasserIn]
Van de Walle, Gerlinde R [VerfasserIn]

Links:

Volltext

Themen:

Cancer
Cancer resistance
Journal Article
Metastasis
Non-traditional model organisms
Research Support, Non-U.S. Gov't
Review
Sentinel
Spontaneous tumors
Tumor microenvironment

Anmerkungen:

Date Completed 25.11.2021

Date Revised 25.11.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1007/s10555-020-09930-6

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM316798150