Local Recurrence Following Total Marrow Radiation : Implications for Clinical Target Delineation

Copyright © 2020, Hara et al..

Total marrow radiation is an emerging treatment modality used in patients undergoing stem cell transplantation. We present a rare case of a patient undergoing total marrow irradiation with concurrent ablative stem cell transplantation with local failures in two out-of-field areas that were not included in the clinical target volume A 31-year-old female patient initially presented with abdominal pain secondary to chronic myelogenous leukemia. She underwent dasatinib treatment for years, but subsequently developed recurrence and underwent consolidation systemic chemotherapy followed by allogeneic stem cell transplantation with adjuvant total marrow irradiation. Several months later, she noticed increased left jaw swelling and dysphagia with associated right ankle swelling. Biopsy of the right ankle and left mandible were consistent with recurrent myeloid sarcoma. This case report suggests that inclusion of the mandible and lower extremities may be necessary when performing total marrow radiation.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:12

Enthalten in:

Cureus - 12(2020), 9 vom: 22. Sept., Seite e10592

Sprache:

Englisch

Beteiligte Personen:

Hara, Jared H [VerfasserIn]
Ahn, Kang-Hyun [VerfasserIn]
Aydogan, Bulent [VerfasserIn]
Koshy, Matthew [VerfasserIn]

Links:

Volltext

Themen:

Allogeneic bone marrow transplant
Bone marrow failure
Case Reports
Chronic myelogenous leukemia
Hematology-oncology
Myeloid sarcoma
Radiation oncology
Total marrow irradiation
Volumetric-modulated arc therapy

Anmerkungen:

Date Revised 29.10.2020

published: Electronic

Citation Status PubMed-not-MEDLINE

doi:

10.7759/cureus.10592

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM31679385X