Clinical, radiographic, and patient-centered outcomes after use of enamel matrix proteins for the treatment of intrabony defects in patients with aggressive periodontitis : A 12-month multicenter clinical trial

© 2020 American Academy of Periodontology..

BACKGROUND: The aim of this study was to evaluate the clinical, radiographic and patient-centered results of enamel matrix derivative (EMD) therapy in intrabony defects in aggressive periodontitis (AgP) patients and compare them with those in chronic periodontitis (CP) patients.

METHODS: Sixty intrabony defects in AgP and CP patients associated with ≥ 6 mm residual probing pocket depth (PPD) were included and randomly assigned to one of three groups: AgP+CS (conservative surgery) (n = 20); AgP+CS/EMD (n = 20); CP+CS/EMD (n  =  20). Clinical parameters were measured at baseline and after 6 and 12 months. Defect resolution (DR) and bone filling (BF) were used for radiographic analysis. The quality of life was recorded at baseline and 6 months using OHIP-14 and VAS scale in the early post-therapy period.

RESULTS: PPD and relative clinical attachment level (rCAL) improved for all groups during follow-up (P ≤ 0.05), and AgP+CS/EMD presented a higher rCAL gain (2.4 ± 1.0 mm) when compared to AgP control patients (1.6 ± 1.6 mm, P ≤ 0.05) after 12 months. No difference was observed between AgP+CS/EMD and CP+CS/EMD groups (P > 0.05). No radiographic differences were observed among groups at any time point (P > 0.05). All the groups reported a positive impact on OHIP-14 total score, without differences among them.

CONCLUSIONS: EMD therapy of intrabony defects promotes additional benefits in AgP patients, presenting a similar regeneration rate compared to CP patients, and has proven to be a viable therapy for the treatment of individuals with AgP.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:92

Enthalten in:

Journal of periodontology - 92(2021), 7 vom: 27. Juli, Seite 995-1006

Sprache:

Englisch

Beteiligte Personen:

Fileto Mazzonetto, Ana Lívia [VerfasserIn]
Casarin, Renato Corrêa Viana [VerfasserIn]
Santamaria, Mauro Pedrine [VerfasserIn]
Andere, Naira Maria Rebelatto Bechara [VerfasserIn]
Araújo, Cássia Fernandes [VerfasserIn]
Videira Clima da Silva, Rafaela [VerfasserIn]
Purisaca, Javier Eduardo Vivanco [VerfasserIn]
Sallum, Enilson Antonio [VerfasserIn]
Sallum, Antonio Wilson [VerfasserIn]

Links:

Volltext

Themen:

Aggressive periodontitis
Alveolar bone loss
Chronic periodontitis
Dental Enamel Proteins
Enamel matrix proteins
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Anmerkungen:

Date Completed 04.08.2021

Date Revised 31.05.2022

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1002/JPER.20-0493

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM316763179