Clinical, radiographic, and patient-centered outcomes after use of enamel matrix proteins for the treatment of intrabony defects in patients with aggressive periodontitis : A 12-month multicenter clinical trial
© 2020 American Academy of Periodontology..
BACKGROUND: The aim of this study was to evaluate the clinical, radiographic and patient-centered results of enamel matrix derivative (EMD) therapy in intrabony defects in aggressive periodontitis (AgP) patients and compare them with those in chronic periodontitis (CP) patients.
METHODS: Sixty intrabony defects in AgP and CP patients associated with ≥ 6 mm residual probing pocket depth (PPD) were included and randomly assigned to one of three groups: AgP+CS (conservative surgery) (n = 20); AgP+CS/EMD (n = 20); CP+CS/EMD (n = 20). Clinical parameters were measured at baseline and after 6 and 12 months. Defect resolution (DR) and bone filling (BF) were used for radiographic analysis. The quality of life was recorded at baseline and 6 months using OHIP-14 and VAS scale in the early post-therapy period.
RESULTS: PPD and relative clinical attachment level (rCAL) improved for all groups during follow-up (P ≤ 0.05), and AgP+CS/EMD presented a higher rCAL gain (2.4 ± 1.0 mm) when compared to AgP control patients (1.6 ± 1.6 mm, P ≤ 0.05) after 12 months. No difference was observed between AgP+CS/EMD and CP+CS/EMD groups (P > 0.05). No radiographic differences were observed among groups at any time point (P > 0.05). All the groups reported a positive impact on OHIP-14 total score, without differences among them.
CONCLUSIONS: EMD therapy of intrabony defects promotes additional benefits in AgP patients, presenting a similar regeneration rate compared to CP patients, and has proven to be a viable therapy for the treatment of individuals with AgP.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2021 |
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Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:92 |
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Enthalten in: |
Journal of periodontology - 92(2021), 7 vom: 27. Juli, Seite 995-1006 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Fileto Mazzonetto, Ana Lívia [VerfasserIn] |
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Links: |
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Anmerkungen: |
Date Completed 04.08.2021 Date Revised 31.05.2022 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1002/JPER.20-0493 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM316763179 |
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100 | 1 | |a Fileto Mazzonetto, Ana Lívia |e verfasserin |4 aut | |
245 | 1 | 0 | |a Clinical, radiographic, and patient-centered outcomes after use of enamel matrix proteins for the treatment of intrabony defects in patients with aggressive periodontitis |b A 12-month multicenter clinical trial |
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520 | |a © 2020 American Academy of Periodontology. | ||
520 | |a BACKGROUND: The aim of this study was to evaluate the clinical, radiographic and patient-centered results of enamel matrix derivative (EMD) therapy in intrabony defects in aggressive periodontitis (AgP) patients and compare them with those in chronic periodontitis (CP) patients | ||
520 | |a METHODS: Sixty intrabony defects in AgP and CP patients associated with ≥ 6 mm residual probing pocket depth (PPD) were included and randomly assigned to one of three groups: AgP+CS (conservative surgery) (n = 20); AgP+CS/EMD (n = 20); CP+CS/EMD (n = 20). Clinical parameters were measured at baseline and after 6 and 12 months. Defect resolution (DR) and bone filling (BF) were used for radiographic analysis. The quality of life was recorded at baseline and 6 months using OHIP-14 and VAS scale in the early post-therapy period | ||
520 | |a RESULTS: PPD and relative clinical attachment level (rCAL) improved for all groups during follow-up (P ≤ 0.05), and AgP+CS/EMD presented a higher rCAL gain (2.4 ± 1.0 mm) when compared to AgP control patients (1.6 ± 1.6 mm, P ≤ 0.05) after 12 months. No difference was observed between AgP+CS/EMD and CP+CS/EMD groups (P > 0.05). No radiographic differences were observed among groups at any time point (P > 0.05). All the groups reported a positive impact on OHIP-14 total score, without differences among them | ||
520 | |a CONCLUSIONS: EMD therapy of intrabony defects promotes additional benefits in AgP patients, presenting a similar regeneration rate compared to CP patients, and has proven to be a viable therapy for the treatment of individuals with AgP | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Multicenter Study | |
650 | 4 | |a Randomized Controlled Trial | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a aggressive periodontitis | |
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650 | 7 | |a enamel matrix proteins |2 NLM | |
700 | 1 | |a Casarin, Renato Corrêa Viana |e verfasserin |4 aut | |
700 | 1 | |a Santamaria, Mauro Pedrine |e verfasserin |4 aut | |
700 | 1 | |a Andere, Naira Maria Rebelatto Bechara |e verfasserin |4 aut | |
700 | 1 | |a Araújo, Cássia Fernandes |e verfasserin |4 aut | |
700 | 1 | |a Videira Clima da Silva, Rafaela |e verfasserin |4 aut | |
700 | 1 | |a Purisaca, Javier Eduardo Vivanco |e verfasserin |4 aut | |
700 | 1 | |a Sallum, Enilson Antonio |e verfasserin |4 aut | |
700 | 1 | |a Sallum, Antonio Wilson |e verfasserin |4 aut | |
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