Effect of poor glycemic control in cognitive performance in the elderly with type 2 diabetes mellitus : The Mexican Health and Aging Study
BACKGROUND: Cognitive impairment is twice more frequent in elderly with type 2 diabetes mellitus (DM). This study was conducted to determine the association between glycemic control and cognitive performance among community-dwelling elderly persons in Mexico.
METHODS: Cross-sectional study conducted in individuals aged 60 years or elderly participating in the 2012 Mexican Health and Aging Study. Type 2 DM participants were classified in 3 groups according to their glycated hemoglobin levels (HbA1c): < 7% (intensive control), 7-7.9% (standard control) or ≥ 8% (poor control), and cognitive performance: low (CCCE ≤44 points), intermediate (44.1-59.52 points), or high (≥59.53 points). Multinomial logistic regression models were constructed to determine this association.
RESULTS: Two hundred sixteen community-dwelling adults aged 60 and older with type 2 diabetes were selected. Subjects in the low cognitive performance group were older (69.7 ± 6.6 vs 65.86 ± 5.18 years, p < .001) and had a lower educational level (2.5 ± 2.6 vs 7.44 ± 4.15 years, p < .000) when compared to the high cognitive performance participants. HbA1c ≥ 8% was associated with having low (Odds Ratio (OR) 3.17, 95% CI 1.17-8.60, p = .024), and intermediate (OR 3.23, 95% CI 1.27-8.20, p = .014) cognitive performance; this trend was not found for HbA1c 7.0-7.9% group. The multinomial regression analysis showed that the presence of HbA1c ≥ 8% (poor glycemic control) was associated with low (OR 3.17, 95% CI = 1.17-8.60, p = .024), and intermediate (OR 3.23, 95% CI = 1.27-8.20, p = .014) cognitive performance. After adjusting for confounding variables.
CONCLUSIONS: Glycemic control with a HbA1c ≥ 8% was associated with worse cognitive performance.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
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| Enthalten in: |
BMC geriatrics - 20(2020), 1 vom: 23. Okt., Seite 424 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mimenza-Alvarado, Alberto J [VerfasserIn] |
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| Links: |
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| Themen: |
Blood Glucose |
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| Anmerkungen: |
Date Completed 21.12.2020 Date Revised 21.12.2020 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12877-020-01827-x |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM316658618 |
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| 100 | 1 | |a Mimenza-Alvarado, Alberto J |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effect of poor glycemic control in cognitive performance in the elderly with type 2 diabetes mellitus |b The Mexican Health and Aging Study |
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| 500 | |a Date Completed 21.12.2020 | ||
| 500 | |a Date Revised 21.12.2020 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Cognitive impairment is twice more frequent in elderly with type 2 diabetes mellitus (DM). This study was conducted to determine the association between glycemic control and cognitive performance among community-dwelling elderly persons in Mexico | ||
| 520 | |a METHODS: Cross-sectional study conducted in individuals aged 60 years or elderly participating in the 2012 Mexican Health and Aging Study. Type 2 DM participants were classified in 3 groups according to their glycated hemoglobin levels (HbA1c): < 7% (intensive control), 7-7.9% (standard control) or ≥ 8% (poor control), and cognitive performance: low (CCCE ≤44 points), intermediate (44.1-59.52 points), or high (≥59.53 points). Multinomial logistic regression models were constructed to determine this association | ||
| 520 | |a RESULTS: Two hundred sixteen community-dwelling adults aged 60 and older with type 2 diabetes were selected. Subjects in the low cognitive performance group were older (69.7 ± 6.6 vs 65.86 ± 5.18 years, p < .001) and had a lower educational level (2.5 ± 2.6 vs 7.44 ± 4.15 years, p < .000) when compared to the high cognitive performance participants. HbA1c ≥ 8% was associated with having low (Odds Ratio (OR) 3.17, 95% CI 1.17-8.60, p = .024), and intermediate (OR 3.23, 95% CI 1.27-8.20, p = .014) cognitive performance; this trend was not found for HbA1c 7.0-7.9% group. The multinomial regression analysis showed that the presence of HbA1c ≥ 8% (poor glycemic control) was associated with low (OR 3.17, 95% CI = 1.17-8.60, p = .024), and intermediate (OR 3.23, 95% CI = 1.27-8.20, p = .014) cognitive performance. After adjusting for confounding variables | ||
| 520 | |a CONCLUSIONS: Glycemic control with a HbA1c ≥ 8% was associated with worse cognitive performance | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Cognitive performance | |
| 650 | 4 | |a Elderly persons | |
| 650 | 4 | |a Glycemic control | |
| 650 | 4 | |a Type 2 diabetes mellitus | |
| 650 | 7 | |a Blood Glucose |2 NLM | |
| 700 | 1 | |a Jiménez-Castillo, Gilberto A |e verfasserin |4 aut | |
| 700 | 1 | |a Yeverino-Castro, Sara G |e verfasserin |4 aut | |
| 700 | 1 | |a Barragán-Berlanga, Abel J |e verfasserin |4 aut | |
| 700 | 1 | |a Pérez-Zepeda, Mario U |e verfasserin |4 aut | |
| 700 | 1 | |a Ávila-Funes, J Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Aguilar-Navarro, Sara G |e verfasserin |4 aut | |
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