Phenotyping the Association between Nocturia and Hypertension : A Systematic Review and Meta-Analysis

PURPOSE: The association between nocturia and hypertension has been widely reported yet remains poorly characterized, precluding a more refined understanding of blood pressure as it relates to the clinical urology setting. We synthesized current evidence on the relationship between nocturia and hypertension as a function of nocturia severity, age, gender, race, body mass index and diuretic use.

MATERIALS AND METHODS: We searched PubMed®, EMBASE® and Cochrane databases for studies published up to May 2020. Random effects meta-analyses were performed to identify pooled odds ratios for nocturia given the presence of hypertension. Meta-regression and subgroup analyses were performed to identify differences across study samples.

RESULTS: Of 1,193 identified studies, 25 met the criteria for inclusion. The overall pooled OR for the association of nocturia with hypertension was 1.25 (95% CI 1.21-1.28, p <0.001). Pooled estimates were 1.20 (1.16-1.25, p <0.001) and 1.30 (1.25-1.36, p <0.001) using a 1-void and 2-void cutoff for nocturia, respectively (p <0.001 between cutoffs). The association was more robust in patient-based (1.74 [1.54-1.98], p <0.001) vs community-based (1.24 [1.24-1.29], p <0.001) study samples (p <0.001). The association was stronger in females compared to males (1.45 [1.32-1.58] vs 1.28 [1.22-1.35], p <0.001), and Black (1.56 [1.25-1.94]) and Asian (1.28 [1.23-1.33]) vs White subgroups (1.16 [1.08-1.24]; p <0.05 for both). No effect was observed for age or body mass index. Evidence on diuretics was limited.

CONCLUSIONS: Hypertension is associated with a 1.2-fold to 1.3-fold higher risk of nocturia. This association is more robust at a higher nocturia cutoff, in patient-based study samples, among females and in Black and Asian patients, but unrelated to age or body mass index.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:205

Enthalten in:

The Journal of urology - 205(2021), 6 vom: 01. Juni, Seite 1577-1583

Sprache:

Englisch

Beteiligte Personen:

Rahman, Syed N [VerfasserIn]
Cao, Daniel J [VerfasserIn]
Monaghan, Thomas F [VerfasserIn]
Flores, Viktor X [VerfasserIn]
Vaysblat, Michael [VerfasserIn]
Moy, Matthew W [VerfasserIn]
Agudelo, Christina W [VerfasserIn]
Lazar, Jason M [VerfasserIn]
Weiss, Jeffrey P [VerfasserIn]

Links:

Volltext

Themen:

Arteries
Cardiology
Cardiovascular system
Hypertension
Journal Article
Meta-Analysis
Nocturia
Systematic Review

Anmerkungen:

Date Completed 15.07.2021

Date Revised 15.07.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1097/JU.0000000000001433

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM316508527