Shifting hierarchy of the conjunctival florae in the patients employed a long-time topical fluoroquinolone
International Journal of Ophthalmology Press..
AIM: To observe the shifting hierarchy of the conjunctival florae in the patients who employed a long-time topical fluoroquinolone and characterize the consequent variations of their antibiotic sensitivity and virulence.
METHODS: A total of 143 eyes (143 patients) who suffered from the non-infectious corneal ulcer and topically used fluoroquinolone more than 2wk were enrolled as the fluoroquinolone eye. The untreated fellow eye was considered as the contralateral eye. Seventy-five healthy subjects were selected as the control. The culture positivity and strains of the isolated conjunctival florae were observed. Their antibiotic susceptibility and expression of the virulence-related genes were detected.
RESULTS: Florae were recovered from 84.0%, 37.1%, and 57.3% of the conjunctival swabs in the control, fluoroquinolone eye, and contralateral eye, respectively. The most frequently isolated microorganisms were Staphylococcus epidermidis (34.9%) in the control, followed by Staphylococcus aureus (17.5%), Staphylococcus saprophyticus (14.3%), Micrococcus (9.5%), Propionibacterium acnes (7.9%). However, those orderly ranks shifted to Staphylococcus aureus (34.0%), Propionibacterium acnes (20.8%), Candida albicans (17.0%), Pseudomonas aeruginosa (9.4%) in the fluoroquinolone eye. A growing number of the fluoroquinolone-resistant florae survived in the fluoroquinolone eye, accompanied by an increased expression of the virulence-related genes.
CONCLUSION: A long-time topical fluoroquinolone leads to a shifting hierarchy of the conjunctival florae, accompanied by the consequent variations of the antibiotic sensitivity and virulence.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
International journal of ophthalmology - 13(2020), 10 vom: 14., Seite 1554-1560 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Xue-Hui [VerfasserIn] |
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| Links: |
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| Themen: |
Antibiotic sensitivity |
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| Anmerkungen: |
Date Revised 22.10.2020 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.18240/ijo.2020.10.07 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM316474150 |
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| 100 | 1 | |a Zhang, Xue-Hui |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Shifting hierarchy of the conjunctival florae in the patients employed a long-time topical fluoroquinolone |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Revised 22.10.2020 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a International Journal of Ophthalmology Press. | ||
| 520 | |a AIM: To observe the shifting hierarchy of the conjunctival florae in the patients who employed a long-time topical fluoroquinolone and characterize the consequent variations of their antibiotic sensitivity and virulence | ||
| 520 | |a METHODS: A total of 143 eyes (143 patients) who suffered from the non-infectious corneal ulcer and topically used fluoroquinolone more than 2wk were enrolled as the fluoroquinolone eye. The untreated fellow eye was considered as the contralateral eye. Seventy-five healthy subjects were selected as the control. The culture positivity and strains of the isolated conjunctival florae were observed. Their antibiotic susceptibility and expression of the virulence-related genes were detected | ||
| 520 | |a RESULTS: Florae were recovered from 84.0%, 37.1%, and 57.3% of the conjunctival swabs in the control, fluoroquinolone eye, and contralateral eye, respectively. The most frequently isolated microorganisms were Staphylococcus epidermidis (34.9%) in the control, followed by Staphylococcus aureus (17.5%), Staphylococcus saprophyticus (14.3%), Micrococcus (9.5%), Propionibacterium acnes (7.9%). However, those orderly ranks shifted to Staphylococcus aureus (34.0%), Propionibacterium acnes (20.8%), Candida albicans (17.0%), Pseudomonas aeruginosa (9.4%) in the fluoroquinolone eye. A growing number of the fluoroquinolone-resistant florae survived in the fluoroquinolone eye, accompanied by an increased expression of the virulence-related genes | ||
| 520 | |a CONCLUSION: A long-time topical fluoroquinolone leads to a shifting hierarchy of the conjunctival florae, accompanied by the consequent variations of the antibiotic sensitivity and virulence | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a antibiotic sensitivity | |
| 650 | 4 | |a conjunctival flora | |
| 650 | 4 | |a corneal ulcer | |
| 650 | 4 | |a fluoroquinolone | |
| 650 | 4 | |a virulence | |
| 700 | 1 | |a Tian, Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Wen, Yi-Yi |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Shuang-Yong |e verfasserin |4 aut | |
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