The myodural bridge of the American alligator (Alligator mississippiensis) alters CSF flow

© 2020. Published by The Company of Biologists Ltd..

Disorders of the volume, pressure or circulation of the cerebrospinal fluid (CSF) lead to disease states in both newborns and adults; despite this significance, there is uncertainty regarding the basic mechanics of the CSF. The suboccipital muscles connect to the dura surrounding the spinal cord, forming a complex termed the 'myodural bridge'. This study tests the hypothesis that the myodural bridge functions to alter the CSF circulation. The suboccipital muscles of American alligators were surgically exposed and electrically stimulated simultaneously with direct recordings of CSF pressure and flow. Contraction of the suboccipital muscles significantly changed both CSF flow and pressure. By demonstrating another influence on CSF circulation and pulsatility, the present study increases our understanding of the mechanics underlying the movement of the CSF.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:223

Enthalten in:

The Journal of experimental biology - 223(2020), Pt 22 vom: 23. Nov.

Sprache:

Englisch

Beteiligte Personen:

Young, Bruce A [VerfasserIn]
Adams, James [VerfasserIn]
Beary, Jonathan M [VerfasserIn]
Mardal, Kent-Andre [VerfasserIn]
Schneider, Robert [VerfasserIn]
Kondrashova, Tatyana [VerfasserIn]

Links:

Volltext

Themen:

Crocodilia
Fluid mechanics
Journal Article
Meninges
Neuroscience
Skeletal muscle

Anmerkungen:

Date Completed 18.06.2021

Date Revised 23.08.2023

published: Electronic

Citation Status MEDLINE

doi:

10.1242/jeb.230896

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM316469661