Commentary on human pluripotent stem cell-based blood-brain barrier models
In 2012, we provided the first published evidence that human pluripotent stem cells could be differentiated to cells exhibiting markers and phenotypes characteristic of the blood-brain barrier (BBB). In the ensuing years, the initial protocols have been refined, and the research community has identified both positive and negative attributes of this stem cell-based BBB model system. Here, we give our perspective on the current status of these models and their use in the BBB community, as well as highlight key attributes that would benefit from improvement moving forward.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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| Enthalten in: |
Fluids and barriers of the CNS - 17(2020), 1 vom: 19. Okt., Seite 64 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lippmann, Ethan S [VerfasserIn] |
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| Links: |
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| Themen: |
Blood–brain barrier |
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| Anmerkungen: |
Date Completed 16.08.2021 Date Revised 16.08.2021 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12987-020-00222-3 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM316462802 |
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| 520 | |a In 2012, we provided the first published evidence that human pluripotent stem cells could be differentiated to cells exhibiting markers and phenotypes characteristic of the blood-brain barrier (BBB). In the ensuing years, the initial protocols have been refined, and the research community has identified both positive and negative attributes of this stem cell-based BBB model system. Here, we give our perspective on the current status of these models and their use in the BBB community, as well as highlight key attributes that would benefit from improvement moving forward | ||
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