Characterization of the intestinal microbiota during Citrobacter rodentium infection in a mouse model of infection-triggered Parkinson's disease
Parkinson's disease (PD) is a neurodegenerative disorder that has been shown to be influenced by the intestinal milieu. The gut microbiota is altered in PD patients, and murine studies have begun suggesting a causative role for the gut microbiota in progression of PD. We have previously shown that repeated infection with the intestinal murine pathogen Citrobacter rodentium resulted in the development of PD-like pathology in Pink1-/- mice compared to wild-type littermates. This addendum aims to expand this work by characterizing the gut microbiota during C. rodentium infection in our Pink1-/- PD model. We observed little disturbance to the fecal microbiota diversity both between infection timepoints and between Pink1-/- and wild-type control littermates. However, the level of short-chain fatty acids appeared to be altered over the course of infection with butyric acid significantly increasing in Pink1-/- mice and isobutyric acid increasing in wild-type mice.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Gut microbes - 12(2020), 1 vom: 09. Nov., Seite 1-11 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cannon, Tyler [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 27.09.2021 Date Revised 27.09.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1080/19490976.2020.1830694 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM316344443 |
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| 245 | 1 | 0 | |a Characterization of the intestinal microbiota during Citrobacter rodentium infection in a mouse model of infection-triggered Parkinson's disease |
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| 500 | |a Date Revised 27.09.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Parkinson's disease (PD) is a neurodegenerative disorder that has been shown to be influenced by the intestinal milieu. The gut microbiota is altered in PD patients, and murine studies have begun suggesting a causative role for the gut microbiota in progression of PD. We have previously shown that repeated infection with the intestinal murine pathogen Citrobacter rodentium resulted in the development of PD-like pathology in Pink1-/- mice compared to wild-type littermates. This addendum aims to expand this work by characterizing the gut microbiota during C. rodentium infection in our Pink1-/- PD model. We observed little disturbance to the fecal microbiota diversity both between infection timepoints and between Pink1-/- and wild-type control littermates. However, the level of short-chain fatty acids appeared to be altered over the course of infection with butyric acid significantly increasing in Pink1-/- mice and isobutyric acid increasing in wild-type mice | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Gut microbiota | |
| 650 | 4 | |a Parkinson’s disease | |
| 650 | 4 | |a autoimmunity | |
| 650 | 4 | |a gut-brain axis | |
| 650 | 4 | |a infection | |
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| 650 | 7 | |a Protein Kinases |2 NLM | |
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| 700 | 1 | |a Sinha, Anshul |e verfasserin |4 aut | |
| 700 | 1 | |a Trudeau, Louis-Eric |e verfasserin |4 aut | |
| 700 | 1 | |a Maurice, Corinne F |e verfasserin |4 aut | |
| 700 | 1 | |a Gruenheid, Samantha |e verfasserin |4 aut | |
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