Are Genome-Wide Association Study Identified Single-Nucleotide Polymorphisms Associated With Sprint Athletic Status? A Replication Study With 3 Different Cohorts
PURPOSE: To replicate previous genome-wide association study identified sprint-related polymorphisms in 3 different cohorts of top-level sprinters and to further validate the obtained results in functional studies.
METHODS: A total of 240 Japanese, 290 Russians, and 593 Brazilians were evaluated in a case-control approach. Of these, 267 were top-level sprint/power athletes. In addition, the relationship between selected polymorphisms and muscle fiber composition was evaluated in 203 Japanese and 287 Finnish individuals.
RESULTS: The G allele of the rs3213537 polymorphism was overrepresented in Japanese (odds ratio [OR]: 2.07, P = .024) and Russian (OR: 1.93, P = .027) sprinters compared with endurance athletes and was associated with an increased proportion of fast-twitch muscle fibers in Japanese (P = .02) and Finnish (P = .041) individuals. A meta-analysis of the data from 4 athlete cohorts confirmed that the presence of the G/G genotype rather than the G/A+A/A genotypes increased the OR of being a sprinter compared with controls (OR: 1.49, P = .01), endurance athletes (OR: 1.79, P = .001), or controls + endurance athletes (OR: 1.58, P = .002). Furthermore, male sprinters with the G/G genotype were found to have significantly faster personal times in the 100-m dash than those with G/A+A/A genotypes (10.50 [0.26] vs 10.76 [0.31], P = .014).
CONCLUSION: The rs3213537 polymorphism found in the CPNE5 gene was identified as a highly replicable variant associated with sprinting ability and the increased proportion of fast-twitch muscle fibers, in which the homozygous genotype for the major allele (ie, the G/G genotype) is preferable for performance.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:16 |
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| Enthalten in: |
International journal of sports physiology and performance - 16(2021), 4 vom: 01. Apr., Seite 489-495 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Guilherme, João Paulo Limongi França [VerfasserIn] |
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| Links: |
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| Themen: |
Athletes |
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| Anmerkungen: |
Date Completed 07.06.2021 Date Revised 20.04.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1123/ijspp.2019-1032 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM316288691 |
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| 100 | 1 | |a Guilherme, João Paulo Limongi França |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Are Genome-Wide Association Study Identified Single-Nucleotide Polymorphisms Associated With Sprint Athletic Status? A Replication Study With 3 Different Cohorts |
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| 500 | |a Date Completed 07.06.2021 | ||
| 500 | |a Date Revised 20.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a PURPOSE: To replicate previous genome-wide association study identified sprint-related polymorphisms in 3 different cohorts of top-level sprinters and to further validate the obtained results in functional studies | ||
| 520 | |a METHODS: A total of 240 Japanese, 290 Russians, and 593 Brazilians were evaluated in a case-control approach. Of these, 267 were top-level sprint/power athletes. In addition, the relationship between selected polymorphisms and muscle fiber composition was evaluated in 203 Japanese and 287 Finnish individuals | ||
| 520 | |a RESULTS: The G allele of the rs3213537 polymorphism was overrepresented in Japanese (odds ratio [OR]: 2.07, P = .024) and Russian (OR: 1.93, P = .027) sprinters compared with endurance athletes and was associated with an increased proportion of fast-twitch muscle fibers in Japanese (P = .02) and Finnish (P = .041) individuals. A meta-analysis of the data from 4 athlete cohorts confirmed that the presence of the G/G genotype rather than the G/A+A/A genotypes increased the OR of being a sprinter compared with controls (OR: 1.49, P = .01), endurance athletes (OR: 1.79, P = .001), or controls + endurance athletes (OR: 1.58, P = .002). Furthermore, male sprinters with the G/G genotype were found to have significantly faster personal times in the 100-m dash than those with G/A+A/A genotypes (10.50 [0.26] vs 10.76 [0.31], P = .014) | ||
| 520 | |a CONCLUSION: The rs3213537 polymorphism found in the CPNE5 gene was identified as a highly replicable variant associated with sprinting ability and the increased proportion of fast-twitch muscle fibers, in which the homozygous genotype for the major allele (ie, the G/G genotype) is preferable for performance | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a sprint performance | |
| 650 | 4 | |a synaptic plasticity | |
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| 650 | 7 | |a Intracellular Signaling Peptides and Proteins |2 NLM | |
| 700 | 1 | |a Semenova, Ekaterina A |e verfasserin |4 aut | |
| 700 | 1 | |a Zempo, Hirofumi |e verfasserin |4 aut | |
| 700 | 1 | |a Martins, Gabriel L |e verfasserin |4 aut | |
| 700 | 1 | |a Lancha Junior, Antonio H |e verfasserin |4 aut | |
| 700 | 1 | |a Miyamoto-Mikami, Eri |e verfasserin |4 aut | |
| 700 | 1 | |a Kumagai, Hiroshi |e verfasserin |4 aut | |
| 700 | 1 | |a Tobina, Takuro |e verfasserin |4 aut | |
| 700 | 1 | |a Shiose, Keisuke |e verfasserin |4 aut | |
| 700 | 1 | |a Kakigi, Ryo |e verfasserin |4 aut | |
| 700 | 1 | |a Tsuzuki, Takamasa |e verfasserin |4 aut | |
| 700 | 1 | |a Ichinoseki-Sekine, Noriko |e verfasserin |4 aut | |
| 700 | 1 | |a Kobayashi, Hiroyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Naito, Hisashi |e verfasserin |4 aut | |
| 700 | 1 | |a Borisov, Oleg V |e verfasserin |4 aut | |
| 700 | 1 | |a Kostryukova, Elena S |e verfasserin |4 aut | |
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| 700 | 1 | |a Generozov, Edward V |e verfasserin |4 aut | |
| 700 | 1 | |a Fuku, Noriyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Ahmetov, Ildus I |e verfasserin |4 aut | |
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