The role of Beta-1 receptor gene polymorphism in Beta-Blocker therapy for vasovagal syncope

BACKGROUND: Vasovagal syncope (VVS) is a common clinical condition involving genetic background. The role of beta-blockers in the treatment is controversial.

OBJECTIVE: The aim of this study was to investigate the effect of beta-1 gene polymorphism on beta-blocker therapy in patients with VVS.

METHODS: We included 123 patients who were diagnosed with VVS after the tilttable test. We searched for the polymorphism Arg389Gly (rs1801253) in the beta-1 adrenoceptor gene.

RESULTS: Overall, 64 patients (52%) had Arg389Arg with Arg389Arg genotype were more frequent compared with patients having Arg389Gly genotype (total syncopal episodes [TSE], 7.9 ± 3.7 vs. 6.4 ± 3.0; p = 0.012). TSE in patients with Arg389Arg genotype decreased significantly after 18 months of beta-blocker treatment (7.9 ± 3.7 vs. 3.0 ± 1.4, p < 0.001). After 18 months of beta-blocker treatment, patients with Arg389Arg genotype had significantly fewer syncopal episodes than patients with Arg389Gly genotype (3.0 ± 1.4 vs. 6.8 ± 3.2, p < 0.001).

CONCLUSIONS: Results of beta-blocker therapy in patients with Arg389Arg genotype suggest that VVS pathophysiology is a multifactorial condition, with genetic, psychological, and environmental components, and therefore, treatment selection can be based on gene polymorphism.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:72

Enthalten in:

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion - 72(2020), 5 vom: 07. Mai

Sprache:

Englisch

Beteiligte Personen:

Atici, Adem [VerfasserIn]
Rasih-Sonsoz, Mehmet [VerfasserIn]
Ali-Barman, Hasan [VerfasserIn]
Durmaz, Eser [VerfasserIn]
Demirkiran, Ahmet [VerfasserIn]
Gulsen, Kamil [VerfasserIn]
Elitok, Ali [VerfasserIn]
Onur, Imran [VerfasserIn]
Sahin, Irfan [VerfasserIn]
Kaya Bilge, Ahmet [VerfasserIn]

Links:

Volltext

Themen:

Journal Article

Anmerkungen:

Date Revised 22.02.2024

published: Print-Electronic

Citation Status Publisher

doi:

10.24875/RIC.20003319

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM316232122